SYN2 Antibody – Rabbit Polyclonal

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]

SYN2: neuronal phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal and to the cytoskeleton. May function in the regulation of neurotransmitter release and synaptogenesis. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing results in two isoforms.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: synaptic vesicle membrane; synapse; cell junction

Molecular Function: catalytic activity; ATP binding

Biological Process: synaptic transmission; metabolic process; neurotransmitter secretion

Disease: Schizophrenia