• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ALDH5A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2528983

This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALDH5A1, Polyclonal Antibody
Full Product Name
ALDH5A1 Polyclonal Antibody
Product Gene Name
anti-ALDH5A1 antibody
Product Synonym Names
SSDH; SSADH
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.4mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
58,653 Da
OMIM
271980
Immunogen
Synthetic peptide of human ALDH5A1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALDH5A1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ALDH5A1 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-ALDH5A1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ALDH5A1 Polyclonal Antibody at dilution 1:60
Rabbit Anti-ALDH5A1 Polyclonal Antibody – Cat# MBS2528983

Immunohistochemistry (IHC) of anti-ALDH5A1 antibody

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ALDH5A1 Polyclonal Antibody at dilution 1:60
Rabbit Anti-ALDH5A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2528983

Other Notes

Small volumes of anti-ALDH5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH5A1 purchase

MBS2528983 is an antibody targeting ALDH5A1. Also known as ALDH5A1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH5A1. It may not necessarily be applicable to this product.

NCBI GI #
608785145
NCBI GeneID
7915
NCBI Accession #
AHW56409.1
UniProt Secondary Accession #
Q546H9; Q8N3W6; B2RD26; G5E949
UniProt Related Accession #
P51649
NCBI Official Full Name
aldehyde dehydrogenase 5 family member A1 isoform A, partial
NCBI Official Synonym Full Names
aldehyde dehydrogenase 5 family, member A1
NCBI Official Symbol
ALDH5A1
NCBI Official Synonym Symbols
SSDH; SSADH
UniProt Protein Name
Succinate-semialdehyde dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase
UniProt Gene Name
ALDH5A1
UniProt Synonym Gene Names
SSADH
UniProt Entry Name
SSDH_HUMAN
NCBI Protein Information
succinate-semialdehyde dehydrogenase, mitochondrial; NAD(+)-dependent succinic semialdehyde dehydrogenase; aldehyde dehydrogenase 5 family member A1; mitochondrial succinate semialdehyde dehydrogenase

UniProt Comments for ALDH5A1

ALDH5A1: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency). SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development. Belongs to the aldehyde dehydrogenase family.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Oxidoreductase; Carbohydrate Metabolism - butanoate; Mitochondrial; EC 1.2.1.24

Chromosomal Location of Human Ortholog: 6p22

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; succinate-semialdehyde dehydrogenase activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity

Biological Process: succinate metabolic process; glutamate metabolic process; central nervous system development; neurotransmitter catabolic process; short-chain fatty acid metabolic process; neurotransmitter secretion; acetate metabolic process; glucose metabolic process; glutamine metabolic process; glucosylceramide metabolic process; protein homotetramerization; post-embryonic development; synaptic transmission; glutathione metabolic process; galactosylceramide metabolic process; glycerophospholipid metabolic process; gamma-aminobutyric acid catabolic process

Disease: Succinic Semialdehyde Dehydrogenase Deficiency
Show more

Research Articles on ALDH5A1

1. Results show that opioid-dependent patients carrying the T allele of a functional variant in ALDH5A1 had a greater risk of being nonresponders to methadone maintenance treatment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALDH5A1 antibody

 Reference Product  PubMed Publications
 ABAT antibody  >1 publications with ALDH5A1 and ABAT

Pathways associated with anti-ALDH5A1 antibody

 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Degradation Of GABA Pathway antibodies  Degradation Of GABA Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with anti-ALDH5A1 antibody

 Disease Name  Pubmed Publications
 succinic semialdehyde dehydrogenase deficiency Antibodies  >51 publications with ALDH5A1 and succinic semialdehyde dehydrogenase deficiency
 Nervous System Diseases Antibodies  >38 publications with ALDH5A1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with ALDH5A1 and Disease Models, Animal
 Intellectual Disability Antibodies  >9 publications with ALDH5A1 and Intellectual Disability
 Brain Diseases, Metabolic Antibodies  >6 publications with ALDH5A1 and Brain Diseases, Metabolic
 Poisoning Antibodies  >3 publications with ALDH5A1 and Poisoning
 Liver Diseases Antibodies  >2 publications with ALDH5A1 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with ALDH5A1 and Kidney Diseases
 Adenocarcinoma Antibodies  >2 publications with ALDH5A1 and Adenocarcinoma
 Neurotoxicity Syndromes Antibodies  >2 publications with ALDH5A1 and Neurotoxicity Syndromes

Organs/Tissues associated with anti-ALDH5A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >59 publications with ALDH5A1 and Brain
 Liver Antibodies  >13 publications with ALDH5A1 and Liver
 Muscle Antibodies  >8 publications with ALDH5A1 and Muscle
 Kidney Antibodies  >5 publications with ALDH5A1 and Kidney
 Embryonic Tissue Antibodies  >4 publications with ALDH5A1 and Embryonic Tissue
 Eye Antibodies  >3 publications with ALDH5A1 and Eye
 Heart Antibodies  >2 publications with ALDH5A1 and Heart
 Intestine Antibodies  >1 publications with ALDH5A1 and Intestine
 Ovary Antibodies  >1 publications with ALDH5A1 and Ovary
 Pancreas Antibodies  >1 publications with ALDH5A1 and Pancreas
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000