FBXO31 Antibody – Rabbit Polyclonal

FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: cell soma; SCF ubiquitin ligase complex

Molecular Function: cyclin binding

Biological Process: G1 DNA damage checkpoint; cyclin catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus

Disease: Mental Retardation, Autosomal Recessive 45