DNAJC3 Antibody – Rabbit Polyclonal

DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.

Protein type: Chaperone; Endoplasmic reticulum; Inhibitor; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 13q32.1

Cellular Component: smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; cytoplasm; vesicle

Molecular Function: protein kinase inhibitor activity; chaperone binding; misfolded protein binding

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; proteolysis involved in cellular protein catabolic process; unfolded protein response; negative regulation of protein kinase activity; defense response to virus; negative regulation of apoptosis

Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus