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FKBP8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2535789

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FKBP8, Polyclonal Antibody
Full Product Name
FKBP8 Polyclonal Antibody
Product Gene Name
anti-FKBP8 antibody
Product Synonym Names
FKBP38; FKBPr38
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 45kDa
OMIM
604840
Immunogen
Recombinant protein of human FKBP8
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46334 / sc-46333 / sc-66894
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FKBP8 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-FKBP8 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-100

Western Blot (WB) of anti-FKBP8 antibody

Western blot analysis of extracts of various cell lines, using FKBP8 antibody.
Rabbit Anti-FKBP8 Polyclonal Antibody – Cat# MBS2535789

Other Notes

Small volumes of anti-FKBP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP8 purchase

MBS2535789 is an antibody targeting FKBP8. Also known as FKBP8 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP8. It may not necessarily be applicable to this product.

NCBI GI #
35384711
NCBI GeneID
23770
NCBI Accession #
AAQ84561.1
UniProt Secondary Accession #
Q53GU3; Q7Z349; Q86YK6; C8C9T5
UniProt Related Accession #
Q14318
NCBI Official Full Name
FKBP8
NCBI Official Synonym Full Names
FK506 binding protein 8
NCBI Official Symbol
FKBP8
NCBI Official Synonym Symbols
FKBP38; FKBPr38
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP8
UniProt Synonym Protein Names
38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase
Protein Family
Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name
FKBP8
UniProt Synonym Gene Names
FKBP38; PPIase FKBP8; 38 kDa FKBP; FKBP-38; hFKBP38; FKBP-8
UniProt Entry Name
FKBP8_HUMAN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP8

UniProt Comments for FKBP8

FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Isomerase; EC 5.2.1.8; Chaperone; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane; mitochondrial membrane

Molecular Function: FK506 binding; identical protein binding; metal ion binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: apoptosis; camera-type eye development; cell fate specification; dorsoventral neural tube patterning; multicellular organism growth; negative regulation of apoptosis; positive regulation of BMP signaling pathway; protein peptidyl-prolyl isomerization; smoothened signaling pathway; viral reproduction
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Research Articles on FKBP8

1. The information presented here provides important clues for understanding the catalytic activity of FKBP38, its regulation by the unique N-terminal extension, and the potential calcium- and calmodulin-mediated activation of FKBP38.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FKBP8 antibody

 Reference Product  PubMed Publications
 MTOR antibody  >12 publications with FKBP8 and MTOR
 BCL2L1 antibody  >9 publications with FKBP8 and BCL2L1
 RHEB antibody  >8 publications with FKBP8 and RHEB
 EGLN1 antibody  >3 publications with FKBP8 and EGLN1
 PTPLAD1 antibody  >2 publications with FKBP8 and PTPLAD1
 KCNH2 antibody  >1 publications with FKBP8 and KCNH2
 BCL2 antibody  >1 publications with FKBP8 and BCL2

Pathways associated with anti-FKBP8 antibody

 Products by Pathway  Pathway Diagram
 Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies  Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram

Diseases associated with anti-FKBP8 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with FKBP8 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >6 publications with FKBP8 and Congenital Abnormalities
 Liver Diseases Antibodies  >5 publications with FKBP8 and Liver Diseases
 Brain Diseases Antibodies  >3 publications with FKBP8 and Brain Diseases
 Neoplasm Metastasis Antibodies  >2 publications with FKBP8 and Neoplasm Metastasis
 Fibrosis Antibodies  >2 publications with FKBP8 and Fibrosis
 Fever Antibodies  >1 publications with FKBP8 and Fever
 Liver Neoplasms Antibodies  >1 publications with FKBP8 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with FKBP8 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with FKBP8 and Kidney Diseases

Organs/Tissues associated with anti-FKBP8 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with FKBP8 and Liver
 Brain Antibodies  >6 publications with FKBP8 and Brain
 Nerve Antibodies  >4 publications with FKBP8 and Nerve
 Kidney Antibodies  >3 publications with FKBP8 and Kidney
 Bone Antibodies  >2 publications with FKBP8 and Bone
 Embryonic Tissue Antibodies  >2 publications with FKBP8 and Embryonic Tissue
 Ganglia Antibodies  >2 publications with FKBP8 and Ganglia
 Eye Antibodies  >2 publications with FKBP8 and Eye
 Ovary Antibodies  >1 publications with FKBP8 and Ovary
 Blood Antibodies  >1 publications with FKBP8 and Blood
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