PTN Antibody – Rabbit Polyclonal

PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: basement membrane; cell surface; endoplasmic reticulum; extracellular space; membrane; neuromuscular junction; perinuclear region of cytoplasm

Molecular Function: growth factor activity; heparin binding; protein phosphatase inhibitor activity

Biological Process: bone mineralization; cerebellum development; endothelial cell differentiation; heart development; learning; liver development; lung development; negative regulation of angiogenesis; negative regulation of catalytic activity; negative regulation of cell migration; negative regulation of epithelial cell proliferation; negative regulation of membrane potential; nervous system development; positive regulation of apoptosis; positive regulation of cell division; positive regulation of cell proliferation; regulation of cell shape; response to activity; response to drug; response to estradiol stimulus; response to progesterone stimulus; spinal cord development; thalamus development; transmembrane receptor protein tyrosine phosphatase signaling pathway