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CLIC4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2539541

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride… More details

$265 / 0.06 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLIC4, Polyclonal Antibody
Full Product Name
CLIC4 Polyclonal Antibody
Product Gene Name
anti-CLIC4 antibody
Product Synonym Names
H1; huH1; p64H1; CLIC4L; MTCLIC
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 29kDa
OMIM
606536
Immunogen
Recombinant protein of human CLIC4
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-65033 / sc-65035 / sc-65034 / sc-130723
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CLIC4 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CLIC4 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-100

Western Blot (WB) of anti-CLIC4 antibody

Western blot analysis of extracts of various cell lines, using CLIC4 antibody.
Rabbit Anti-CLIC4 Polyclonal Antibody – Cat# MBS2539541

Other Notes

Small volumes of anti-CLIC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLIC4 purchase

MBS2539541 is an antibody targeting CLIC4. Also known as CLIC4 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLIC4. It may not necessarily be applicable to this product.

NCBI GI #
7330335
NCBI GeneID
25932
NCBI Accession #
NP_039234.1
UniProt Secondary Accession #
Q9UFW9; Q9UQJ6
UniProt Related Accession #
Q9Y696
GenBank Nucleotide #
NM_013943.2
NCBI Official Full Name
chloride intracellular channel protein 4
NCBI Official Synonym Full Names
chloride intracellular channel 4
NCBI Official Symbol
CLIC4
NCBI Official Synonym Symbols
H1; huH1; p64H1; CLIC4L; MTCLIC
UniProt Protein Name
Chloride intracellular channel protein 4
UniProt Synonym Protein Names
Intracellular chloride ion channel protein p64H1
Protein Family
Chloride intracellular channel protein
UniProt Gene Name
CLIC4
UniProt Entry Name
CLIC4_HUMAN
NCBI Protein Information
chloride intracellular channel protein 4

UniProt Comments for CLIC4

CLIC4: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: actin cytoskeleton; apical part of cell; cell surface; centrosome; cytoplasm; cytoplasmic vesicle membrane; cytosol; intercellular junction; intracellular; microtubule cytoskeleton; microvillus; midbody; mitochondrion; nuclear matrix; perinuclear region of cytoplasm; plasma membrane

Molecular Function: chloride channel activity; glutathione transferase activity; protein binding; voltage-gated ion channel activity

Biological Process: angiogenesis; apoptosis; branching morphogenesis of a tube; cell differentiation; chloride transport; endothelial cell morphogenesis; establishment and/or maintenance of apical/basal cell polarity; fertilization; glutathione metabolic process; keratinocyte differentiation; multicellular organism growth; negative regulation of cell migration; regulation of cytoskeleton organization and biogenesis; vacuolar acidification
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Research Articles on CLIC4

1. CLIC1 and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLIC4 antibody

 Reference Product  PubMed Publications
 HIVEP2 antibody  >1 publications with CLIC4 and HIVEP2
 MMP9 antibody  >1 publications with CLIC4 and MMP9
 BMPR2 antibody  >1 publications with CLIC4 and BMPR2
 TP53 antibody  >1 publications with CLIC4 and TP53
 AKAP9 antibody  >1 publications with CLIC4 and AKAP9

Diseases associated with anti-CLIC4 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with CLIC4 and Nervous System Diseases
 Inflammation Antibodies  >7 publications with CLIC4 and Inflammation
 Necrosis Antibodies  >5 publications with CLIC4 and Necrosis
 Lung Diseases Antibodies  >4 publications with CLIC4 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with CLIC4 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >3 publications with CLIC4 and Carcinoma
 Hypertension Antibodies  >3 publications with CLIC4 and Hypertension
 Neoplasms, Experimental Antibodies  >3 publications with CLIC4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with CLIC4 and Lung Neoplasms
 Disease Models, Animal Antibodies  >2 publications with CLIC4 and Disease Models, Animal

Organs/Tissues associated with anti-CLIC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with CLIC4 and Brain
 Vascular Antibodies  >11 publications with CLIC4 and Vascular
 Blood Antibodies  >11 publications with CLIC4 and Blood
 Muscle Antibodies  >9 publications with CLIC4 and Muscle
 Lung Antibodies  >7 publications with CLIC4 and Lung
 Skin Antibodies  >7 publications with CLIC4 and Skin
 Bone Antibodies  >6 publications with CLIC4 and Bone
 Heart Antibodies  >6 publications with CLIC4 and Heart
 Embryonic Tissue Antibodies  >4 publications with CLIC4 and Embryonic Tissue
 Eye Antibodies  >4 publications with CLIC4 and Eye
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