IRS-1 Antibody – Rabbit Polyclonal

IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q36.3

Cellular Component: caveola; cytoplasm; cytosol; insulin receptor complex; intracellular membrane-bound organelle; nucleus; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; insulin-like growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; phosphotyrosine binding; protein binding; protein kinase C binding; Ras guanyl-nucleotide exchange factor activity; SH2 domain binding; signal transducer activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: cellular response to insulin stimulus; glucose homeostasis; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-7-mediated signaling pathway; MAPK cascade; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; phosphatidylinositol phosphorylation; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose import in response to insulin stimulus; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase B signaling; response to insulin stimulus; response to peptide hormone; signal transduction

Disease: Diabetes Mellitus, Noninsulin-dependent