PLK Antibody – Rabbit Polyclonal

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

PLK1: a kinase of the PLK family. Contains a polo-box domain (PBD), a specific phosphoserine or phosphothreonine binding domain. Substrates include BRCA2, Myt1, NudC, Cdc25C, cyclin B1, Nlp and other mitotic proteins. Inhibited by ATR. Plays a role in regulation of cytokinesis and coordinating M-phase events.

Protein type: EC 2.7.11.21; Kinase, protein; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 16p12.2

Cellular Component: centrosome; chromatin; condensed nuclear chromosome outer kinetochore; cytosol; kinetochore; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole; synaptonemal complex

Molecular Function: anaphase-promoting complex binding; ATP binding; identical protein binding; kinase activity; magnesium ion binding; microtubule binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; centrosome cycle; establishment of protein localization; female meiosis chromosome segregation; G2/M transition of mitotic cell cycle; homologous chromosome segregation; microtubule bundle formation; mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; mitotic nuclear envelope disassembly; mitotic sister chromatid segregation; negative regulation of apoptosis; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; nuclear envelope disassembly; peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to nucleus; positive regulation of proteolysis; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein transferase activity; protein amino acid phosphorylation; protein destabilization; protein localization to chromatin; protein localization to nuclear envelope; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of mitotic spindle assembly; regulation of protein binding; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; signal transduction involved in G2 DNA damage checkpoint; sister chromatid cohesion