14-3-3 theta/tau Antibody – Rabbit Polyclonal

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; extracellular exosome; focal adhesion; membrane; mitochondrion; protein complex

Molecular Function: 14-3-3 protein binding; identical protein binding; ion channel binding; protein binding; protein C-terminus binding; protein domain specific binding; protein N-terminus binding

Biological Process: negative regulation of ion transmembrane transport; negative regulation of transcription, DNA-dependent; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein targeting; small GTPase mediated signal transduction; substantia nigra development