P70 S6 Kinase Alpha (RPS6KB1) Antibody – Rabbit Polyclonal

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; Translation; p70 subfamily

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: cell junction; cell surface; cytosol; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; synapse

Molecular Function: ATP binding; identical protein binding; kinase activity; PDZ domain binding; peptide binding; protein binding; protein kinase activity; protein phosphatase 2A binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity

Biological Process: aging; apoptosis; behavioral fear response; cell migration; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; G1/S transition of mitotic cell cycle; germ cell development; long-term memory; negative regulation of apoptosis; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of translational initiation; protein amino acid phosphorylation; protein kinase B signaling; regulation of glucose import; response to drug; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon; response to glucose stimulus; response to heat; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to testosterone stimulus; response to toxin; response to tumor necrosis factor; response to wounding; signal transduction; skeletal muscle atrophy; skeletal muscle contraction; TOR signaling