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SMC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2548875

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance… More details

$160 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SMC1, Polyclonal Antibody
Full Product Name
Phospho-SMC1 (Ser966) Polyclonal Antibody
Product Gene Name
anti-SMC1 antibody
Product Synonym Names
SMC1A; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Molecular Weight
Calculated Molecular Weight: 143kDa
Observed Molecular Weight: 160kDa
OMIM
S78271 mRNA
3D Structure
ModBase 3D Structure for Q14683
Immunogen
Synthesized peptide derived from human SMC1 around the phosphorylation site of S966.
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.

Product Categories/Family for anti-SMC1 antibody

Acetyl/Phospho/Methyl Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SMC1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-SMC1 antibody
WB: 1:500-1:2000
IHC: 1:100-1:300
ELISA: 1:10000

Other Notes

Small volumes of anti-SMC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMC1 purchase

MBS2548875 is an antibody targeting SMC1. Also known as Phospho-SMC1 (Ser966) Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMC1. It may not necessarily be applicable to this product.

NCBI GI #
30581135
NCBI GeneID
8243
NCBI Accession #
NP_006297.2
UniProt Primary Accession #
Q14683
UniProt Secondary Accession #
O14995; Q16351; Q2M228
UniProt Related Accession #
Q14683
GenBank Nucleotide #
NM_006306.3
NCBI Official Full Name
structural maintenance of chromosomes protein 1A isoform 1
NCBI Official Synonym Full Names
structural maintenance of chromosomes 1A
NCBI Official Symbol
SMC1A
NCBI Official Synonym Symbols
SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha
UniProt Protein Name
Structural maintenance of chromosomes protein 1A
UniProt Synonym Protein Names
Sb1.8
Protein Family
Structural maintenance of chromosomes protein
UniProt Gene Name
SMC1A
UniProt Synonym Gene Names
DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; SMC protein 1A; SMC-1-alpha; SMC-1A
NCBI Protein Information
structural maintenance of chromosomes protein 1A

UniProt Comments for SMC1

Smc1: a component of the cohesin multiprotein complex that is required for sister chromatid cohesion. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Thought to be an important part of functional kinetochores. Interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.

Protein type: DNA replication; RNA splicing

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: chromosome; chromosome, centromeric region; cohesin complex; condensed chromosome kinetochore; condensed nuclear chromosome; cytosol; kinetochore; nuclear matrix; nucleoplasm; nucleus

Molecular Function: ATP binding; chromatin binding; protein binding; protein heterodimerization activity; RNA binding

Biological Process: cell division; DNA repair; meiotic cell cycle; mitotic sister chromatid cohesion; mitotic sister chromatid segregation; negative regulation of DNA endoreduplication; regulation of mitotic spindle assembly; response to DNA damage checkpoint signaling; response to radiation; sister chromatid cohesion; stem cell maintenance

Disease: Cornelia De Lange Syndrome 2
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Research Articles on SMC1

1. We conclude that SMC1A variants can result in a phenotype resembling CdLS and a phenotype resembling Rett syndrome. Resemblances between the SMC1A group and the NIPBL group suggest that a disturbed cohesin function contributes to the phenotype, but differences between these groups may also be explained by other underlying mechanisms such as moonlighting of the cohesin genes.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMC1 antibody

 Reference Product  PubMed Publications
 SMC3 antibody  >28 publications with SMC1 and SMC3
 RAD21 antibody  >9 publications with SMC1 and RAD21
 ATM antibody  >1 publications with SMC1 and ATM

Pathways associated with anti-SMC1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Cohesin Loading Onto Chromatin Pathway antibodies  Cohesin Loading Onto Chromatin Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Establishment Of Sister Chromatid Cohesion Pathway antibodies  Establishment Of Sister Chromatid Cohesion Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram

Diseases associated with anti-SMC1 antibody

 Disease Name  Pubmed Publications
 CdLS, X-Linked Antibodies  >37 publications with SMC1 and CdLS, X-Linked
 Neoplasms Antibodies  >5 publications with SMC1 and Neoplasms
 Heart Diseases Antibodies  >4 publications with SMC1 and Heart Diseases
 Death Antibodies  >4 publications with SMC1 and Death
 Cardiomyopathies Antibodies  >1 publications with SMC1 and Cardiomyopathies
 Precancerous Conditions Antibodies  >1 publications with SMC1 and Precancerous Conditions
 Immune System Diseases Antibodies  >1 publications with SMC1 and Immune System Diseases
 Hypertrophy Antibodies  >1 publications with SMC1 and Hypertrophy

Organs/Tissues associated with anti-SMC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >4 publications with SMC1 and Bone
 Heart Antibodies  >4 publications with SMC1 and Heart
 Blood Antibodies  >3 publications with SMC1 and Blood
 Muscle Antibodies  >2 publications with SMC1 and Muscle
 Mouth Antibodies  >2 publications with SMC1 and Mouth
 Lung Antibodies  >2 publications with SMC1 and Lung
 Bone Marrow Antibodies  >2 publications with SMC1 and Bone Marrow
 Eye Antibodies  >2 publications with SMC1 and Eye
 Esophagus Antibodies  >1 publications with SMC1 and Esophagus
 Embryonic Tissue Antibodies  >1 publications with SMC1 and Embryonic Tissue
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