GSK3beta Antibody – Rabbit Polyclonal

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: CMGC group; EC 2.7.11.1; EC 2.7.11.26; GSK family; GSK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: beta-catenin destruction complex; centrosome; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; Wnt signalosome

Molecular Function: ATP binding; beta-catenin binding; kinase activity; NF-kappaB binding; p53 binding; protease binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau-protein kinase activity; ubiquitin protein ligase binding

Biological Process: beta-catenin destruction complex assembly; beta-catenin destruction complex disassembly; cellular response to amyloid-beta; circadian rhythm; dopamine receptor signaling pathway; epithelial to mesenchymal transition; ER overload response; glycogen metabolic process; hippocampus development; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of dopaminergic neuron differentiation; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of neuron death; negative regulation of NFAT protein import into nucleus; negative regulation of protein binding; negative regulation of protein complex assembly; negative regulation of protein localization to nucleus; negative regulation of type B pancreatic cell development; neuron projection development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; protein autophosphorylation; regulation of apoptosis; regulation of cellular response to heat; regulation of microtubule-based process; superior temporal gyrus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway