Glutamate Receptor 1 (GLUR1) Antibody – Rabbit Polyclonal

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q33.2

Cellular Component: axonal spine; cell junction; cell soma; cell surface; dendrite; dendritic spine; early endosome membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; Golgi membrane; neuron spine; plasma membrane; postsynaptic density; postsynaptic density membrane; recycling endosome; recycling endosome membrane; synaptic vesicle

Molecular Function: AMPA glutamate receptor activity; amyloid-beta binding; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; PDZ domain binding; protein binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Biological Process: COPII vesicle coating; ER to Golgi vesicle-mediated transport; excitatory postsynaptic potential; ionotropic glutamate receptor signaling pathway; long-term memory; receptor internalization; signal transduction; synaptic transmission