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CAV1.3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2549342

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cav1.3, Polyclonal Antibody
Full Product Name
Cav1.3 Polyclonal Antibody
Product Gene Name
anti-Cav1.3 antibody
Product Synonym Names
CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Molecular Weight
242,417 Da
OMIM
M76558 mRNA
3D Structure
ModBase 3D Structure for Q01668
Immunogen
Synthetic Peptide
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Cav1.3 antibody
Immunohistochemistry (IHC) Paraffin (IHC-p)
Application Notes for anti-Cav1.3 antibody
IHC: 1:100-200

Immunohistochemistry (IHC) of anti-Cav1.3 antibody

Immunohistochemistry of paraffin-embedded Rat brain tissue using Cav1.3 Polyclonal Antibody at dilution of 1:200.
Rabbit Anti-CAV1.3 Polyclonal Antibody – Cat# MBS2549342

Immunohistochemistry (IHC) of anti-Cav1.3 antibody

Immunohistochemistry of paraffin-embedded Mouse brain tissue using Cav1.3 Polyclonal Antibody at dilution of 1:200.
Rabbit Anti-CAV1.3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2549342

Other Notes

Small volumes of anti-Cav1.3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cav1.3 purchase

MBS2549342 is an antibody targeting Cav1.3. Also known as Cav1.3 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cav1.3. It may not necessarily be applicable to this product.

NCBI GI #
4502527
NCBI GeneID
776
NCBI Accession #
NP_000711.1
UniProt Primary Accession #
Q01668
UniProt Secondary Accession #
Q13916; Q13931; Q71UT1; Q9UDC3; B0FYA3
UniProt Related Accession #
Q01668
GenBank Nucleotide #
NM_000720.3
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit alpha-1D isoform a
NCBI Official Synonym Full Names
calcium voltage-gated channel subunit alpha1 D
NCBI Official Symbol
CACNA1D
NCBI Official Synonym Symbols
CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt Synonym Protein Names
Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
CACNA1D
UniProt Synonym Gene Names
CACH3; CACN4; CACNL1A2; CCHL1A2
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1D

UniProt Comments for Cav1.3

CACNA1D: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: plasma membrane; voltage-gated calcium channel complex; Z disc

Molecular Function: alpha-actinin binding; ankyrin binding; high voltage-gated calcium channel activity; metal ion binding; voltage-gated calcium channel activity

Biological Process: calcium ion transport; G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of calcium ion transport; regulation of insulin secretion; sensory perception of sound

Disease: Primary Aldosteronism, Seizures, And Neurologic Abnormalities; Sinoatrial Node Dysfunction And Deafness
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Research Articles on Cav1.3

1. These results provide the evidence of a direct regulatory role of Snapin on Cav1.3 channels in atrial myocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cav1.3 antibody

 Reference Product  PubMed Publications
 RYR2 antibody  >9 publications with Cav1.3 and RYR2
 CACNA2D1 antibody  >5 publications with Cav1.3 and CACNA2D1
 CACNB2 antibody  >4 publications with Cav1.3 and CACNB2
 CACNB4 antibody  >1 publications with Cav1.3 and CACNB4
 CACNB3 antibody  >1 publications with Cav1.3 and CACNB3

Pathways associated with anti-Cav1.3 antibody

 Products by Pathway  Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram

Diseases associated with anti-Cav1.3 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >30 publications with Cav1.3 and Hypertension
 Adenoma Antibodies  >26 publications with Cav1.3 and Adenoma
 Hyperaldosteronism Antibodies  >22 publications with Cav1.3 and Hyperaldosteronism
 Cardiovascular Diseases Antibodies  >18 publications with Cav1.3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >17 publications with Cav1.3 and Disease Models, Animal
 Deafness Antibodies  >15 publications with Cav1.3 and Deafness
 Hyperplasia Antibodies  >12 publications with Cav1.3 and Hyperplasia
 Brain Diseases Antibodies  >11 publications with Cav1.3 and Brain Diseases
 Arrhythmias, Cardiac Antibodies  >11 publications with Cav1.3 and Arrhythmias, Cardiac
 Bradycardia Antibodies  >8 publications with Cav1.3 and Bradycardia

Organs/Tissues associated with anti-Cav1.3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >95 publications with Cav1.3 and Brain
 Heart Antibodies  >36 publications with Cav1.3 and Heart
 Muscle Antibodies  >31 publications with Cav1.3 and Muscle
 Pancreas Antibodies  >13 publications with Cav1.3 and Pancreas
 Eye Antibodies  >12 publications with Cav1.3 and Eye
 Kidney Antibodies  >9 publications with Cav1.3 and Kidney
 Adrenal Gland Antibodies  >9 publications with Cav1.3 and Adrenal Gland
 Prostate Antibodies  >8 publications with Cav1.3 and Prostate
 Bone Antibodies  >5 publications with Cav1.3 and Bone
 Intestine Antibodies  >3 publications with Cav1.3 and Intestine
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