HIC-5 Antibody – Rabbit Polyclonal

Hic-5: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Up-regulated by TNF and hydrogen peroxide. Expressed in platelets, smooth muscle and prostate stromal cells. Belongs to the paxillin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytoskeleton; extracellular matrix; focal adhesion; intracellular; nuclear matrix

Molecular Function: androgen receptor binding; I-SMAD binding; metal ion binding; protein binding; Roundabout binding; transcription coactivator activity

Biological Process: androgen receptor signaling pathway; cell adhesion; cell fate commitment; epithelial cell differentiation; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; response to heat; transcription from RNA polymerase II promoter; ubiquitin-dependent SMAD protein catabolic process; Wnt signaling pathway