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PCBD1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2562917

This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a… More details

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Product Overview

Online Datasheet in PDF
Product Name
PCBD1, Polyclonal Antibody
Full Product Name
PCBD1 Polyclonal Antibody
Product Gene Name
anti-PCBD1 antibody
Product Synonym Names
4 alpha hydroxy tetrahydropterin dehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; DCoH; Dimerization cofactor of hepatic nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Dimerization cofactor of HNF1; Dimerizing cofactor for HNF1; PCBD 1; PCBD; PCBD1; PCD; Phenylalanine hydroxylase stimulating protein; Phenylalanine hydroxylase-stimulating protein; PHS; PHS; Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Pterin carbinolamine dehydratase; Pterin-4-alpha-carbinolamine dehydratase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purity/Purification
Antigen Affinity Purification
Concentration
1.62mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
12 kDa
OMIM
126090
3D Structure
ModBase 3D Structure for P61457
Immunogen
Fusion protein of human PCBD1
Conjugation
Unconjugated

Product Categories/Family for anti-PCBD1 antibody

Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PCBD1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-PCBD1 antibody
WB: 1:500-1:2000
IHC: 1:80-1:400
ELISA: 1:5000-1:10000

Western Blot (WB) of anti-PCBD1 antibody

Western blot analysis of Human fetal liver tissue lysate using PCBD1 Polyclonal Antibody at dilution of 1:1000
Rabbit Anti-PCBD1 Polyclonal Antibody – Cat# MBS2562917

Immunohistochemistry (IHC) of anti-PCBD1 antibody

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using PCBD1 Polyclonal Antibody at dilution of 1:90(×200)
Rabbit Anti-PCBD1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2562917

Immunohistochemistry (IHC) of anti-PCBD1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PCBD1 Polyclonal Antibody at dilution of 1:90(×200)
Rabbit Anti-PCBD1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2562917

Other Notes

Small volumes of anti-PCBD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PCBD1 purchase

MBS2562917 is an antibody targeting PCBD1. Also known as PCBD1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PCBD1. It may not necessarily be applicable to this product.

NCBI GI #
4557831
NCBI GeneID
5092
NCBI Accession #
NP_000272.1
NCBI Related Accession #
BC006324
UniProt Primary Accession #
P61457
UniProt Related Accession #
P61457
GenBank Nucleotide #
NP_000272.1
NCBI Official Full Name
pterin-4-alpha-carbinolamine dehydratase isoform 1
NCBI Official Synonym Full Names
pterin-4 alpha-carbinolamine dehydratase 1
NCBI Official Symbol
PCBD1
NCBI Official Synonym Symbols
PCD; PHS; DCOH; PCBD
UniProt Protein Name
Pterin-4-alpha-carbinolamine dehydratase
UniProt Synonym Protein Names
4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD
Protein Family
Pterin-4-alpha-carbinolamine dehydratase
UniProt Gene Name
PCBD1
UniProt Synonym Gene Names
DCOH; PCBD; PHS; DCoH; Dimerization cofactor of HNF1; PCD
UniProt Entry Name
PHS_HUMAN
NCBI Protein Information
pterin-4-alpha-carbinolamine dehydratase

UniProt Comments for PCBD1

PCBD1: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-deficient hyperphenylalaninemia type D (HPABH4D); also known as hyperphenylalaninemia with primapterinuria. HPABH4D is characterized by the excretion of 7-substituted pterins in the urine of affected patients. Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Protein type: Transcription, coactivator/corepressor; Oxidoreductase; Lyase; EC 4.2.1.96

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: identical protein binding; protein binding; 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; transcription coactivator activity; phenylalanine 4-monooxygenase activity

Biological Process: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process; transcription, DNA-dependent; protein heterooligomerization; regulation of protein homodimerization activity; positive regulation of transcription, DNA-dependent; protein homotetramerization

Disease: Hyperphenylalaninemia, Bh4-deficient, D
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Research Articles on PCBD1

1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PCBD1 antibody

 Reference Product  PubMed Publications
 GCH1 antibody  >3 publications with PCBD1 and GCH1
 QDPR antibody  >3 publications with PCBD1 and QDPR
 PAH antibody  >3 publications with PCBD1 and PAH
 HNF1B antibody  >1 publications with PCBD1 and HNF1B
 HNF1A antibody  >1 publications with PCBD1 and HNF1A

Pathways associated with anti-PCBD1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Phenylalanine And Tyrosine Catabolism Pathway antibodies  Phenylalanine And Tyrosine Catabolism Pathway Diagram

Diseases associated with anti-PCBD1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with PCBD1 and Cardiovascular Diseases
 Brain Diseases Antibodies  >2 publications with PCBD1 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with PCBD1 and Nervous System Diseases
 Weight Gain Antibodies  >1 publications with PCBD1 and Weight Gain
 Disease Models, Animal Antibodies  >1 publications with PCBD1 and Disease Models, Animal
 Hypertension Antibodies  >1 publications with PCBD1 and Hypertension
 Kidney Diseases Antibodies  >1 publications with PCBD1 and Kidney Diseases
 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, D Antibodies  >1 publications with PCBD1 and HYPERPHENYLALANINEMIA, BH4-DEFICIENT, D

Organs/Tissues associated with anti-PCBD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with PCBD1 and Kidney
 Pancreas Antibodies  >2 publications with PCBD1 and Pancreas
 Nerve Antibodies  >1 publications with PCBD1 and Nerve
 Embryonic Tissue Antibodies  >1 publications with PCBD1 and Embryonic Tissue
 Bone Antibodies  >1 publications with PCBD1 and Bone
 Heart Antibodies  >1 publications with PCBD1 and Heart
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