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PAM16 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2562929

This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PAM16, Polyclonal Antibody
Full Product Name
PAM16 Polyclonal Antibody
Product Gene Name
anti-PAM16 antibody
Product Synonym Names
CGI-136; MAGMAS; Magmas like protein; Mitochondria associated protein involved in granulocyte macrophage colony stimulating factor signal transduction; Mitochondria-associated granulocyte macrophage CSF-signaling molecule; Mitochondrial import inner membrane translocase subunit TIM16; PAM16; Presequence translocase-associated motor 16 homolog (S. cerevisiae); Presequence translocated-associated motor subunit PAM16; TIM16; TIM16; TIMM16
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purity/Purification
Antigen Affinity Purification
Concentration
0.9mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
14 kDa
OMIM
613320
3D Structure
ModBase 3D Structure for Q9Y3D7
Immunogen
Fusion protein of human PAM16
Conjugation
Unconjugated

Product Categories/Family for anti-PAM16 antibody

Cancer; Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PAM16 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-PAM16 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ELISA: 1:5000-1:10000

Western Blot (WB) of anti-PAM16 antibody

Western blot analysis of HepG2 and Jurkat cell lysates using PAM16 Polyclonal Antibody at dilution of 1:700
Rabbit Anti-PAM16 Polyclonal Antibody – Cat# MBS2562929

Immunohistochemistry (IHC) of anti-PAM16 antibody

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PAM16 Polyclonal Antibody at dilution of 1:50(×200)
Rabbit Anti-PAM16 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2562929

Other Notes

Small volumes of anti-PAM16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAM16 purchase

MBS2562929 is an antibody targeting PAM16. Also known as PAM16 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAM16. It may not necessarily be applicable to this product.

NCBI GI #
27363461
NCBI GeneID
51025
NCBI Accession #
NP_057153.8
NCBI Related Accession #
BC005024
UniProt Primary Accession #
Q9Y3D7
UniProt Related Accession #
Q9Y3D7
GenBank Nucleotide #
NP_057153.8
NCBI Official Full Name
mitochondrial import inner membrane translocase subunit TIM16
NCBI Official Synonym Full Names
presequence translocase associated motor 16
NCBI Official Symbol
PAM16
NCBI Official Synonym Symbols
TIM16; MAGMAS; SMDMDM; TIMM16; CGI-136
UniProt Protein Name
Mitochondrial import inner membrane translocase subunit TIM16
UniProt Synonym Protein Names
Mitochondria-associated granulocyte macrophage CSF-signaling molecule; Presequence translocated-associated motor subunit PAM16
Protein Family
Mitochondrial import inner membrane translocase
UniProt Gene Name
PAM16
UniProt Synonym Gene Names
MAGMAS; TIM16; TIMM16
UniProt Entry Name
TIM16_HUMAN
NCBI Protein Information
mitochondrial import inner membrane translocase subunit TIM16

NCBI Summary for PAM16

This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities. [provided by RefSeq, May 2017]
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UniProt Comments for PAM16

Magmas: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. Belongs to the TIM16/PAM16 family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: mitochondrial matrix; protein complex

Molecular Function: protein binding

Biological Process: cellular protein metabolic process; negative regulation of ATPase activity; ossification; protein import into mitochondrial matrix; protein targeting to mitochondrion

Disease: Spondylometaphyseal Dysplasia, Megarbane-dagher-melki Type
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Research Articles on PAM16

1. Findings demonstrate that Magmas is overexpressed in tissue sections from glioma patients and xenografts. In vivo studies showed that a novel Magmas small molecule inhibitor, BT#9, could cross the BBB in mice. In vitro studies revealed that BT#9 significantly decreased cell proliferation, induced apoptosis, and blocked migration and invasion.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PAM16 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram

Diseases associated with anti-PAM16 antibody

 Disease Name  Pubmed Publications
 Cardiomyopathies Antibodies  >1 publications with PAM16 and Cardiomyopathies

Organs/Tissues associated with anti-PAM16 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with PAM16 and Bone
 Prostate Antibodies  >1 publications with PAM16 and Prostate
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