SUV39H2 Antibody – Rabbit Polyclonal

SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: nucleoplasm; nuclear heterochromatin; chromatin; chromosome, pericentric region

Molecular Function: protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K9 specific); chromatin binding

Biological Process: chromatin assembly or disassembly; chromatin remodeling; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transcription, DNA-dependent; male meiosis