• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS256509

Description: Sp-8-Br-cAMPS is an analogue of the parent compound cyclic AMP in which the hydrogen in position 8 of the nucleobase is replaced by bromine and the axial one of the two exocyclic oxygen atoms in the cyclic phosphate moiety is modified by sulfur.… More details

$505 / 5 umol +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS), Biochemical
Full Product Name
8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS)
Purity/Purification
Typical analysis is better than 98% (HPLC / UV / 264 nm).
The product is not sterile and has not been tested for endotoxins.
Specificity
Lyophilized or crystallized sodium salt. The free acid or other salt forms are available upon request. Equal concentrations of Sp-8-Br-cAMPS can appear very different in volume due to sensitivity of the lyophilized form to humidity. The compound can even contract to small volume droplets. Normally the compound is located in the conical bottom of the tube. Micromolar quantities are determined by UV at λmax
Preparation and Storage
Sp-8-Br-cAMPS has sufficient stability at room temperature and does not need special care during handling. Nevertheless, we recommend that the compound should be stored in the freezer, for longer storage periods preferably in freeze-dried form.
Molecular Weight
446.2
Unit Equivalent
5 umol is approximately equals to 2.2 mg
CAS No.
127634-20-2
Formula
C10H10BrN5O5PS.Na
Properties
Sp-8-Br-cAMPS combines the structures of the two well known protein kinase activators Sp-cAMPS and 8-Br-cAMP yielding a novel membrane permeant cyclic AMP mimetic 1 - 5, 6, 7 which is not degraded by mammalian cyclic nucleotide phosphodiesterases. Sp-8-Br-cAMPS is about 2 times more lipophilic compared to 8-Br-cAMP and Sp-cAMPS and 4 times more compared to cAMP, respectively 8. If you have good or moderate results with 8-Br-cAMP or Sp-cAMPS, you can be sure that Sp-8-Br-cAMPS will be membrane-permeant in your system as well.
Solubility
Detailed information on the solubility of Sp-8-Br-cAMPS in water and various buffers are listed in the solubility chart below.
Concentrations have been tested at ambient temperature and can be considered as minimum concentrations usually obtainable, however, slight batch-to-batch variations cannot be ruled out. When opening the tube please make sure that no substance is lost within the cap. Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Application Notes for 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) biochemical
Applicable concentrations of Sp-8-Br-cAMPS strongly depend on the type of biosystem, its membrane properties and kinase content.
Since Sp-8-Br-cAMPS is hydrolytically stable in mammalian and many other systems, there is no danger of degradation during incubation periods. Sp-8-Br-cAMPS is a good choice, if unwanted side effects of metabolites of hydrolizable cyclic AMP analogues, e.g. 8-Br-cAMP or 8-CPT-cAMP, must be excluded and solely the effect of an intact protein kinase A agonist is desired9.

Structure of 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) biochemical

8- Bromoadenosine- 3', 5'- Cyclic Monophosphorothioate, Sp- Isomer (Sp-8-Br-Camps) Biochemical – Cat# MBS256509

Testing Data (TD) of 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) biochemical

8- Bromoadenosine- 3', 5'- Cyclic Monophosphorothioate, Sp- Isomer (Sp-8-Br-Camps) Biochemical, Testing Data (TD) – Cat# MBS256509

Other Notes

Small volumes of 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) purchase

MBS256509 is a biochemical targeting 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS).
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000