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GCAT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2565416

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GCAT, Polyclonal Antibody
Full Product Name
GCAT Polyclonal Antibody
Product Gene Name
anti-GCAT antibody
Product Synonym Names
GCAT; KBL
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
47,974 Da
OMIM
607422
3D Structure
ModBase 3D Structure for O75600
Immunogen
Recombinant fusion protein of human GCAT (NP_0551061)
Conjugation
Unconjugated

Product Categories/Family for anti-GCAT antibody

Cancer; Metabolism; Signal transduction; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GCAT antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-GCAT antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200

Western Blot (WB) of anti-GCAT antibody

Western blot analysis of extracts of Mouse eye using GCAT Polyclonal Antibody at dilution of 1:1000.
Rabbit Anti-GCAT Polyclonal Antibody – Cat# MBS2565416

Immunohistochemistry (IHC) of anti-GCAT antibody

Immunohistochemistry of paraffin-embedded Human colon carcinoma using GCAT Polyclonal Antibody at dilution of 1:100 (40x lens).
Rabbit Anti-GCAT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2565416

Immunofluorescence (IF) of anti-GCAT antibody

Immunofluorescence analysis of C6 cells using GCAT Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-GCAT Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565416

Other Notes

Small volumes of anti-GCAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCAT purchase

MBS2565416 is an antibody targeting GCAT. Also known as GCAT Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCAT. It may not necessarily be applicable to this product.

NCBI GI #
284448556
NCBI GeneID
23464
NCBI Accession #
NP_001165161.1
UniProt Primary Accession #
O75600
UniProt Secondary Accession #
Q6ZWF1; Q96CA9; E2QC23
UniProt Related Accession #
O75600
GenBank Nucleotide #
NM_001171690.1
NCBI Official Full Name
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 1
NCBI Official Synonym Full Names
glycine C-acetyltransferase
NCBI Official Symbol
GCAT
NCBI Official Synonym Symbols
KBL
UniProt Protein Name
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
UniProt Synonym Protein Names
Aminoacetone synthase; Glycine acetyltransferase
Protein Family
Phosphatidylcholine-sterol acyltransferase
UniProt Gene Name
GCAT
UniProt Synonym Gene Names
KBL; AKB ligase
UniProt Entry Name
KBL_HUMAN
NCBI Protein Information
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; 2-amino-3-ketobutyrate-CoA ligase; AKB ligase; aminoacetone synthase; glycine acetyltransferase

UniProt Comments for GCAT

GCAT: The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Transferase; EC 2.3.1.29

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; mitochondrion

Molecular Function: glycine C-acetyltransferase activity; pyridoxal phosphate binding

Biological Process: amino acid metabolic process; biosynthetic process; threonine catabolic process to pyruvate
Show more

Research Articles on GCAT

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GCAT antibody

 Products by Pathway  Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram

Diseases associated with anti-GCAT antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >1 publications with GCAT and Heart Diseases
 Congenital Abnormalities Antibodies  >1 publications with GCAT and Congenital Abnormalities
 Edema Antibodies  >1 publications with GCAT and Edema
 Hemorrhage Antibodies  >1 publications with GCAT and Hemorrhage
 Inflammation Antibodies  >1 publications with GCAT and Inflammation
 Kidney Diseases Antibodies  >1 publications with GCAT and Kidney Diseases

Organs/Tissues associated with anti-GCAT antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with GCAT and Blood
 Kidney Antibodies  >3 publications with GCAT and Kidney
 Bone Antibodies  >3 publications with GCAT and Bone
 Brain Antibodies  >3 publications with GCAT and Brain
 Skin Antibodies  >2 publications with GCAT and Skin
 Eye Antibodies  >2 publications with GCAT and Eye
 Nerve Antibodies  >1 publications with GCAT and Nerve
 Thymus Antibodies  >1 publications with GCAT and Thymus
 Embryonic Tissue Antibodies  >1 publications with GCAT and Embryonic Tissue
 Heart Antibodies  >1 publications with GCAT and Heart
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