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AQP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2565557

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and… More details

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Product Overview

Online Datasheet in PDF
Product Name
AQP2, Polyclonal Antibody
Full Product Name
AQP2 Polyclonal Antibody
Product Gene Name
anti-AQP2 antibody
Product Synonym Names
AQP2; AQP-CD; WCH-CD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
28,837 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (50344524..50352664). Location: 12q12-q13
OMIM
107777
3D Structure
ModBase 3D Structure for P41181
Immunogen
Recombinant fusion protein of human AQP2 (NP_0004771)
Conjugation
Unconjugated

Product Categories/Family for anti-AQP2 antibody

Cancer; Metabolism; Signal Transduction; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-AQP2 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-AQP2 antibody
IHC: 1:50-1:100
IF: 1:50-1:200

Immunohistochemistry (IHC) of anti-AQP2 antibody

Immunohistochemistry of paraffin-embedded Mouse kidney using AQP2 Polyclonal Antibody at dilution of 1:100 (40x lens).
Rabbit Anti-AQP2 Polyclonal Antibody – Cat# MBS2565557

Immunofluorescence (IF) of anti-AQP2 antibody

Immunofluorescence analysis of Rat kidney cells using AQP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-AQP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565557

Immunofluorescence (IF) of anti-AQP2 antibody

Immunofluorescence analysis of Mouse kidney cells using AQP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-AQP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565557

Immunofluorescence (IF) of anti-AQP2 antibody

Immunofluorescence analysis of Rat kidney cells using AQP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-AQP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565557

Immunofluorescence (IF) of anti-AQP2 antibody

Immunofluorescence analysis of Mouse kidney cells using AQP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-AQP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565557

Immunofluorescence (IF) of anti-AQP2 antibody

Immunofluorescence analysis of Rat kidney cells using AQP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-AQP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565557

Immunofluorescence (IF) of anti-AQP2 antibody

Immunofluorescence analysis of Mouse kidney cells using AQP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-AQP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2565557

Other Notes

Small volumes of anti-AQP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AQP2 purchase

MBS2565557 is an antibody targeting AQP2. Also known as AQP2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AQP2. It may not necessarily be applicable to this product.

NCBI GI #
4502179
NCBI GeneID
359
NCBI Accession #
NP_000477.1
UniProt Primary Accession #
P41181
UniProt Secondary Accession #
Q9UD68
UniProt Related Accession #
P41181
GenBank Nucleotide #
NM_000486.5
NCBI Official Full Name
aquaporin-2
NCBI Official Synonym Full Names
aquaporin 2 (collecting duct)
NCBI Official Symbol
AQP2
NCBI Official Synonym Symbols
AQP-CD; WCH-CD
UniProt Protein Name
Aquaporin-2
UniProt Synonym Protein Names
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
UniProt Gene Name
AQP2
UniProt Synonym Gene Names
AQP-2; AQP-CD
UniProt Entry Name
AQP2_HUMAN
NCBI Protein Information
aquaporin-2; AQP-2; aquaporin-CD; ADH water channel; water-channel aquaporin 2; collecting duct water channel protein; water channel protein for renal collecting duct

UniProt Comments for AQP2

AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Transporter, aquaporin family; Membrane protein, integral; Channel, misc.; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q12-q13

Cellular Component: recycling endosome; protein complex; clathrin-coated vesicle; membrane; rough endoplasmic reticulum; integral to plasma membrane; lysosome; basolateral plasma membrane; early endosome; apical plasma membrane; plasma membrane; trans-Golgi network

Molecular Function: water transporter activity; glycerol transmembrane transporter activity; actin binding; water channel activity; PDZ domain binding; glycerol channel activity

Biological Process: glycerol transport; actin filament depolymerization; cellular water homeostasis; response to glucagon stimulus; apoptosis; water transport; response to lithium ion; cellular response to water deprivation; response to lipopolysaccharide; female pregnancy; excretion; response to salt stress; response to starvation; hyperosmotic response; renal water transport; renal water homeostasis; response to calcium ion; positive regulation of calcium ion transport; transmembrane transport; aging

Disease: Diabetes Insipidus, Nephrogenic, Autosomal
Show more

Research Articles on AQP2

1. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed enormously to our understanding of the mechanisms of urinary concentration and identified the vasopressin receptor AVPR2, as well as the water channel aquaporin-2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AQP2 antibody

 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Regulation Of Water Balance By Renal Aquaporins Pathway antibodies  Regulation Of Water Balance By Renal Aquaporins Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram

Diseases associated with anti-AQP2 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >308 publications with AQP2 and Kidney Diseases
 Diabetes Insipidus, Nephrogenic Antibodies  >231 publications with AQP2 and Diabetes Insipidus, Nephrogenic
 Polyuria Antibodies  >122 publications with AQP2 and Polyuria
 Cardiovascular Diseases Antibodies  >65 publications with AQP2 and Cardiovascular Diseases
 Heart Failure Antibodies  >47 publications with AQP2 and Heart Failure
 Hypertension Antibodies  >44 publications with AQP2 and Hypertension
 Hyponatremia Antibodies  >42 publications with AQP2 and Hyponatremia
 Heart Diseases Antibodies  >41 publications with AQP2 and Heart Diseases
 Brain Diseases Antibodies  >36 publications with AQP2 and Brain Diseases
 Renal Insufficiency Antibodies  >27 publications with AQP2 and Renal Insufficiency

Organs/Tissues associated with anti-AQP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >825 publications with AQP2 and Kidney
 Brain Antibodies  >72 publications with AQP2 and Brain
 Eye Antibodies  >25 publications with AQP2 and Eye
 Testis Antibodies  >8 publications with AQP2 and Testis
 Prostate Antibodies  >3 publications with AQP2 and Prostate
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