2'- Deoxyadenosine- 5'- O- diphosphoribose (dADPR/ 2'-deoxy-ADPR), sodium salt (2'- Deoxyadenosine- 5'- O- Diphosphoribose (Dadpr / 2'-Deoxy-ADPR))

Disodium. Lyophilized or crystallized sodium salt.

Typical analysis is >95% (HPLC/ UV/ 260 nm). The product is not sterile and has not been tested for endotoxins.

Store at -20 degree C
It is chemically rather stable and does not need special care during handling or shipment. Nevertheless, we recommend that the compound should be stored in the freezer, for longer storage periods preferably in freeze-dried form.

543.3

dADPR is soluble to >= 9 mM in water.

111864-49-4

C??H??N?O??P?

dADPR is a Transient Receptor Potential Melastatin 2 (TRPM2) channel superagonist and potential novel second messenger. Endogenous dADPR was detected in Jurkat T lymphocytes (all data according to Fliegert et al., Nat. Chem. Biol., 13, 1036- 1044 (2017)).

lambda max 260 nm, epsilon 15000, pH 7

Equal concentrations of dADPR can appear very different in volume due to sensitivity of the lyophilized form to humidity. The compound can even contract to small volume droplets. Normally the product is located in the conical bottom of the tube. Micromolar quantities are determined by UV at lambda max.
Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please make sure that no substance is lost within the cap.
Please keep in mind, that the in vivo properties of this compound are not sufficiently characterized up to now.