beta- Phenyl- 1, N2- ethenoguanosine- 3', 5'-cyclic monophosphate- [8- thiomethylamido- (octaethoxy)- ethylamidomethylthio- 8] (PET-cGMP-8-TMAmd-(EO)-EAmdMT-8-cGMP-PET), sodium salt

Disodium. Lyophilized or crystallized sodium salt.

Typical analysis is estimated to be >95% (HPLC/ UV/ 271 nm). The remaining uncertainty is due to the polydispersnature of the PEG spacer. The product is not sterile and has not been tested for endotoxins.

Store at -20 degree C
It has sufficient stability at room temperature and doesnot need special care during handling or shipment. Nevertheless, we recommend that the compound should be stored in the freezer,for longer storage periods preferably in freeze-dried form.

1491.3

PET-cGMP-8-TMAmd-(EO)?-EAmdMT-8-cGMP-PET is soluble in water, limits have not been determined.

2201858-61-7

C??H??N??O??P?S?·Na?

Membrane-permeant cGMP dimer with enhanced PKG activation properties by addressing two binding sitessimultaneously with a single molecule. Activation constants of PET-cGMP-8-TMAmd-(EO)8-EAmdMT-8-cGMP-PET in vitro on purified cGMP-dependent protein kinase (PKG) isozymes were measured to be in the range of < 1 nM (PKG Ialpha and PKG Ibeta) and ~35 nM (PKGII).

lambda max 271 nm, epsilon 72000, pH 7

Please keep in mind that equal amounts of the compound may look different in volume. The compound can even contract to small volume droplets. Normally the product is located in the conical bottom of the tube. Micromolar quantities are determined by weight.
Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please makesure that no substance is lost within the cap.
Please keep in mind that the in vivo properties of this compound are not sufficiently characterized up to now.