5'- Triphosphoadenylyl- (3' -->5')- guanosine (pppApG), sodium salt

Pentasodium. Aqueous solution of the sodium salt (10 mM).

Typical purity is >95% (HPLC/ UV/ 256 nm) at time of quality control and packing. However, actual purity depends on storage and transport conditions. The product is not sterile and has not been tested for endotoxins.

Store at -70 degree C
It is most stable when stored as aqueous solution in the freezer (- 20 degree Celsius necessary,- 70 degree recommended), however, at ambient temperature the compound slowly starts to decompose. Thus, in order to maintain its original high quality it is recommended to allow thawing only before using the product. If you will not use up the vial with one application, please aliquot the contents of the vial in order to avoid repeated freeze/thaw cycles for the rest. When making such aliquots, be sure to operate quickly and to freeze the vial again as soon as possible.
Shipping: Dry Ice

852.39

O=C(NC(N)=N1)C2=C1N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(O[C@H]4[C@@H](O)[C@H](N5C=NC6=C5N=CN=C6N)O[C@@H]4COP([O-])(OP(OP([O-])([O-])=O)([O-])=O)=O)([O-])=O)O3)C=N2.[Na+].[Na+].[Na+].[Na+].[Na+]

68892-47-7

C??H??N??O??P?

pppApG is a potential endogenous metabolite of the metazoan second messenger 2',3'-cGAMP (c[G(2',5')pA(3',5')p],Cat. No. C 161) and/or of the bacterial signalling nucleotide 3'3'-cGAMP (c-(ApGp)). Kranzusch et al. (2014) reportedpppApG to be the linear dinucleotide intermediate in the enzymatic production of 3',3'-cGAMP by the Vibrio cholerae pathogenicityfactor DncV.

lambda max 256 nm, epsilon 25050, pH 7

Micromolar quantities are determined by UV at lambda max. When opening the tube please make sure that no liquid is lost within the cap. A short spin down in a bench centrifuge is recommended before use.
Please keep in mind, that the in vivo properties of this compound are not sufficiently characterized up to now.

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.