Rat Anti-CD163 Monoclonal Antibody – Cat# MBS2572121

C57BL/6 murine bone marrow cells are stained with FITC Anti-Mouse/Human CD11b Antibody and Fluor 647 Anti-Mouse CD163 Antibody (Left). Bone marrow cells are stained with FITC Anti-Mouse/Human CD11b Antibody and Fluor 647 Rat IgG2a,kappa Isotype Control (Right).

CD163 Antibody – Rat Monoclonal

Name: CD163 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2572121
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2572121

CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein… More details

$180 / 50 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD163, Monoclonal Antibody

Full Product Name

Fluor 647 Anti-Mouse CD163 Antibody [S15049F]

Product Gene Name

anti-CD163 antibody

Product Synonym Names

M130, MM130, SCARI1

Clonality

Monoclonal

Isotype

Rat IgG2a, kappa

Clone Number

S15049F

Host

Rat

Species Reactivity

Mouse

Form/Format

Liquid

Preparation and Storage

Store at 2~8 degree C and protected from prolonged exposure to light. Do not freeze.

Matching Pairs

Antibody: CD163 (MBS2572121)
Isotype Control: IgG2a Clone #2A3 (MBS2557849)

Molecular Weight

125,292 Da

3D Structure

ModBase 3D Structure for Q2VLH6

Conjugation

Fluor 647

Buffer

PBS with 0.05% Proclin300, 1% Protein protectant

Cellular Localization

Membrane,Secreted

Product Categories/Family for anti-CD163 antibody

FC Antibody

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CD163 antibody

Flow Cytometry (FC/FACS)

Other Notes

Small volumes of anti-CD163 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD163 purchase

MBS2572121 is an antibody targeting CD163. Also known as Fluor 647 Anti-Mouse CD163 Antibody [S15049F]. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD163. It may not necessarily be applicable to this product.

NCBI GI #

341940294

NCBI GeneID

93671

NCBI Accession #

Q2VLH6.2

UniProt Primary Accession #

Q2VLH6

UniProt Secondary Accession #

Q2VLH5; Q99MX8; A6H691

UniProt Related Accession #

Q2VLH6

NCBI Official Full Name

Scavenger receptor cysteine-rich type 1 protein M130

NCBI Official Synonym Full Names

CD163 antigen

NCBI Official Symbol

Cd163

NCBI Official Synonym Symbols

CD163v2; CD163v3

UniProt Protein Name

Scavenger receptor cysteine-rich type 1 protein M130

UniProt Synonym Protein Names

CD_antigen: CD163Cleaved into the following chain:Soluble CD163; sCD163

Protein Family

Scavenger receptor cysteine-rich type 1 protein

UniProt Gene Name

Cd163

UniProt Synonym Gene Names

M130; sCD163

UniProt Entry Name

C163A_MOUSE

NCBI Protein Information

scavenger receptor cysteine-rich type 1 protein M130

UniProt Comments for CD163

CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; extracellular region; plasma membrane; integral to membrane

Molecular Function: scavenger receptor activity

Biological Process: receptor-mediated endocytosis; acute-phase response; inflammatory response

Research Articles on CD163

1. Data indicate an essential substrate motif for ADAM17-mediated CD163 and proTNF-alpha cleavage in macrophages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD163 antibody

Products by Pathway	Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
Macrophage Markers Pathway antibodies	Macrophage Markers Pathway Diagram
Scavenging Of Heme From Plasma Pathway antibodies	Scavenging Of Heme From Plasma Pathway Diagram

Diseases associated with anti-CD163 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>368 publications with CD163 and Inflammation
Necrosis Antibodies	>165 publications with CD163 and Necrosis
Nervous System Diseases Antibodies	>105 publications with CD163 and Nervous System Diseases
Brain Diseases Antibodies	>65 publications with CD163 and Brain Diseases
Fibrosis Antibodies	>56 publications with CD163 and Fibrosis
Lung Diseases Antibodies	>51 publications with CD163 and Lung Diseases
Adenocarcinoma Antibodies	>40 publications with CD163 and Adenocarcinoma
Heart Diseases Antibodies	>30 publications with CD163 and Heart Diseases
Kidney Diseases Antibodies	>27 publications with CD163 and Kidney Diseases
Neoplasms, Experimental Antibodies	>25 publications with CD163 and Neoplasms, Experimental

Organs/Tissues associated with anti-CD163 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>112 publications with CD163 and Skin
Brain Antibodies	>72 publications with CD163 and Brain
Lymph Node Antibodies	>61 publications with CD163 and Lymph Node
Joint Antibodies	>56 publications with CD163 and Joint
Embryonic Tissue Antibodies	>22 publications with CD163 and Embryonic Tissue
Bladder Antibodies	>5 publications with CD163 and Bladder
Mammary Gland Antibodies	>3 publications with CD163 and Mammary Gland
Vagina Antibodies	>1 publications with CD163 and Vagina