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KCNJ12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2573513

This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within… More details

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Product Overview

Online Datasheet in PDF
Product Name
KCNJ12, Polyclonal Antibody
Full Product Name
KCNJ12 Polyclonal Antibody
Product Gene Name
anti-KCNJ12 antibody
Product Synonym Names
KCNJ12; IRK-2; IRK2; KCNJN1; Kir2.2; Kir2.2v; hIRK; hIRK1; hkir2.2x; kcnj12x
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Storage: -20 degree C/One year. Avoid freeze/thaw cycles.
Molecular Weight
433
OMIM
602323
3D Structure
ModBase 3D Structure for Q14500
Immunogen
Recombinant fusion protein of human KCNJ12

Product Categories/Family for anti-KCNJ12 antibody

Antibodies; Primary Antibodies; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KCNJ12 antibody
Western Blot (WB)
Application Notes for anti-KCNJ12 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-KCNJ12 antibody

Western blot analysis of extracts of various cell lines using KCNJ12 Polyclonal Antibody at1:300 dilution.
Rabbit Anti-KCNJ12 Polyclonal Antibody – Cat# MBS2573513

Other Notes

Small volumes of anti-KCNJ12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNJ12 purchase

MBS2573513 is an antibody targeting KCNJ12. Also known as KCNJ12 Polyclonal Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNJ12. It may not necessarily be applicable to this product.

NCBI GI #
77416868
NCBI GeneID
3768
NCBI Accession #
Q14500.2
UniProt Primary Accession #
Q14500
UniProt Secondary Accession #
O43401; Q15756; Q8NG63
UniProt Related Accession #
Q14500
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 12
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 12
NCBI Official Symbol
KCNJ12
NCBI Official Synonym Symbols
IRK2; hIRK; IRK-2; hIRK1; KCNJN1; Kir2.2; Kir2.2v; kcnj12x; hkir2.2x
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 12
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir2.2; IRK-2; Inward rectifier K(+) channel Kir2.2v; Potassium channel, inwardly rectifying subfamily J member 12
Protein Family
ATP-sensitive inward rectifier potassium channel
UniProt Gene Name
KCNJ12
UniProt Synonym Gene Names
IRK2; KCNJN1; IRK-2
UniProt Entry Name
KCJ12_HUMAN
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 12; inward rectifier K(+) channel Kir2.2; inward rectifier K(+) channel Kir2.6; inward rectifier K(+) channel Kir2.2v; potassium channel, inwardly rectifying subfamily J member 12; potassium inwardly-rectif

UniProt Comments for KCNJ12

KCNJ12: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: integral to plasma membrane; plasma membrane; intrinsic to membrane

Molecular Function: inward rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion import; muscle contraction; regulation of heart contraction; potassium ion transport; protein homotetramerization
Show more

Research Articles on KCNJ12

1. Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNJ12 antibody

 Reference Product  PubMed Publications
 KCNJ2 antibody  >6 publications with KCNJ12 and KCNJ2
 KCNJ4 antibody  >3 publications with KCNJ12 and KCNJ4
 KCNJ14 antibody  >2 publications with KCNJ12 and KCNJ14
 DLG1 antibody  >1 publications with KCNJ12 and DLG1

Pathways associated with anti-KCNJ12 antibody

 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Classical Kir Channels Pathway antibodies  Classical Kir Channels Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with anti-KCNJ12 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >5 publications with KCNJ12 and Congenital Abnormalities
 Heart Diseases Antibodies  >3 publications with KCNJ12 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >2 publications with KCNJ12 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >1 publications with KCNJ12 and Hypertrophy
 Atrophy Antibodies  >1 publications with KCNJ12 and Atrophy
 Disease Models, Animal Antibodies  >1 publications with KCNJ12 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with KCNJ12 and Necrosis

Organs/Tissues associated with anti-KCNJ12 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >9 publications with KCNJ12 and Muscle
 Brain Antibodies  >2 publications with KCNJ12 and Brain
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