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GNA11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2574838

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GNA11, Polyclonal Antibody
Full Product Name
GNA11 Polyclonal Antibody
Product Gene Name
anti-GNA11 antibody
Product Synonym Names
GNA11; FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Storage: -20 degree C/One year. Avoid freeze/thaw cycles.
Molecular Weight
359
OMIM
phenotype 615361
3D Structure
ModBase 3D Structure for P29992
Immunogen
A synthetic peptide of human GNA11
Research Area
Signal Transduction

Product Categories/Family for anti-GNA11 antibody

Antibodies; Primary Antibodies; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GNA11 antibody
Immunofluorescence (IF)
Application Notes for anti-GNA11 antibody
IF: 1:50-1:200

Immunofluorescence (IF) of anti-GNA11 antibody

Immunofluorescence analysis of NIH/3T3 cells using GNA11 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-GNA11 Polyclonal Antibody – Cat# MBS2574838

Other Notes

Small volumes of anti-GNA11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNA11 purchase

MBS2574838 is an antibody targeting GNA11. Also known as GNA11 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GNA11. It may not necessarily be applicable to this product.

NCBI GI #
3041682
NCBI GeneID
2767
NCBI Accession #
P29992.2
UniProt Primary Accession #
P29992
UniProt Secondary Accession #
O15109; Q14350; Q6IB00
UniProt Related Accession #
P29992
NCBI Official Full Name
Guanine nucleotide-binding protein subunit alpha-11
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
NCBI Official Symbol
GNA11
NCBI Official Synonym Symbols
FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2
UniProt Protein Name
Guanine nucleotide-binding protein subunit alpha-11
UniProt Synonym Protein Names
Guanine nucleotide-binding protein G(y) subunit alpha
Protein Family
Guanine nucleotide-binding protein
UniProt Gene Name
GNA11
UniProt Synonym Gene Names
GA11; G alpha-11; G-protein subunit alpha-11
UniProt Entry Name
GNA11_HUMAN
NCBI Protein Information
guanine nucleotide-binding protein subunit alpha-11; g alpha-11; G-protein subunit alpha-11; guanine nucleotide-binding protein G(y) subunit alpha

UniProt Comments for GNA11

G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q)

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; regulation of action potential; platelet activation; metabolic process; heart development; pigmentation during development; dopamine receptor, phospholipase C activating pathway; signal transduction; blood coagulation; skeletal development; regulation of melanocyte differentiation

Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii
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Research Articles on GNA11

1. Metastatic uveal melanoma with GNAQ or GNA11 mutations is responsive to PKC inhibitors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GNA11 antibody

 Reference Product  PubMed Publications
 EDNRB antibody  >1 publications with GNA11 and EDNRB

Pathways associated with anti-GNA11 antibody

 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 Acetylcholine Regulates Insulin Secretion Pathway antibodies  Acetylcholine Regulates Insulin Secretion Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram

Diseases associated with anti-GNA11 antibody

 Disease Name  Pubmed Publications
 Melanoma Antibodies  >80 publications with GNA11 and Melanoma
 Uveal melanoma Antibodies  >54 publications with GNA11 and Uveal melanoma
 Skin Diseases Antibodies  >21 publications with GNA11 and Skin Diseases
 Skin Neoplasms Antibodies  >19 publications with GNA11 and Skin Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with GNA11 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >6 publications with GNA11 and Nervous System Diseases
 Breast Neoplasms Antibodies  >4 publications with GNA11 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with GNA11 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with GNA11 and Lung Neoplasms
 Brain Diseases Antibodies  >2 publications with GNA11 and Brain Diseases

Organs/Tissues associated with anti-GNA11 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >25 publications with GNA11 and Skin
 Eye Antibodies  >19 publications with GNA11 and Eye
 Liver Antibodies  >8 publications with GNA11 and Liver
 Brain Antibodies  >7 publications with GNA11 and Brain
 Muscle Antibodies  >6 publications with GNA11 and Muscle
 Heart Antibodies  >6 publications with GNA11 and Heart
 Bone Antibodies  >5 publications with GNA11 and Bone
 Kidney Antibodies  >4 publications with GNA11 and Kidney
 Parathyroid Antibodies  >4 publications with GNA11 and Parathyroid
 Lung Antibodies  >4 publications with GNA11 and Lung
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