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INSIG2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2574854

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
INSIG2, Polyclonal Antibody
Full Product Name
INSIG2 Polyclonal Antibody
Product Gene Name
anti-INSIG2 antibody
Product Synonym Names
INSIG2; INSIG-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Storage: -20 degree C/One year. Avoid freeze/thaw cycles.
Molecular Weight
24,778 Da
OMIM
608660
3D Structure
ModBase 3D Structure for Q9Y5U4
Immunogen
A synthetic peptide of human INSIG2
Research Area
Cancer, Cardiovascular, Metabolism, Signal Transduction

Product Categories/Family for anti-INSIG2 antibody

Antibodies; Primary Antibodies; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-INSIG2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-INSIG2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-INSIG2 antibody

Western blot analysis of extracts of Mouse kidney using INSIG2 Polyclonal Antibody at 1:1000 dilution.
Rabbit Anti-INSIG2 Polyclonal Antibody – Cat# MBS2574854

Western Blot (WB) of anti-INSIG2 antibody

Western blot analysis of extracts of various cell lines using INSIG2 Polyclonal Antibody at 1:1000 dilution.
Rabbit Anti-INSIG2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2574854

Immunohistochemistry (IHC) of anti-INSIG2 antibody

Immunohistochemistry of paraffin-embedded mouse brain using INSIG2 Polyclonal Antibody at dilution of 1:200 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Rabbit Anti-INSIG2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2574854

Immunohistochemistry (IHC) of anti-INSIG2 antibody

Immunohistochemistry of paraffin-embedded rat ovary using INSIG2 Polyclonal Antibody at dilution of 1:200 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Rabbit Anti-INSIG2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2574854

Other Notes

Small volumes of anti-INSIG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INSIG2 purchase

MBS2574854 is an antibody targeting INSIG2. Also known as INSIG2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INSIG2. It may not necessarily be applicable to this product.

NCBI GI #
38327533
NCBI GeneID
51141
NCBI Accession #
NP_057217.2
UniProt Primary Accession #
Q9Y5U4
UniProt Secondary Accession #
Q8TBI8; A8K5W8
UniProt Related Accession #
Q9Y5U4
GenBank Nucleotide #
NM_016133.2
NCBI Official Full Name
insulin-induced gene 2 protein
NCBI Official Synonym Full Names
insulin induced gene 2
NCBI Official Symbol
INSIG2
UniProt Protein Name
Insulin-induced gene 2 protein
Protein Family
Insulin-induced gene 2 protein
UniProt Gene Name
INSIG2
UniProt Synonym Gene Names
INSIG-2
UniProt Entry Name
INSI2_HUMAN
NCBI Protein Information
insulin-induced gene 2 protein

UniProt Comments for INSIG2

INSIG2: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. Belongs to the INSIG family.

Protein type: Endoplasmic reticulum; Transcription, coactivator/corepressor; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: protein binding; transcription factor binding

Biological Process: inner ear morphogenesis; triacylglycerol metabolic process; palate development; middle ear morphogenesis; SREBP-mediated signaling pathway; cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; response to insulin stimulus
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Research Articles on INSIG2

1. This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-INSIG2 antibody

 Reference Product  PubMed Publications
 INSIG1 antibody  >49 publications with INSIG2 and INSIG1
 SCAP antibody  >19 publications with INSIG2 and SCAP
 SREBF2 antibody  >11 publications with INSIG2 and SREBF2
 AMFR antibody  >3 publications with INSIG2 and AMFR
 VCP antibody  >2 publications with INSIG2 and VCP
 RNF139 antibody  >1 publications with INSIG2 and RNF139
 FABP2 antibody  >1 publications with INSIG2 and FABP2

Pathways associated with anti-INSIG2 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway antibodies  Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram

Diseases associated with anti-INSIG2 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >19 publications with INSIG2 and Fatty Liver
 Atherosclerosis Antibodies  >11 publications with INSIG2 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >10 publications with INSIG2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >8 publications with INSIG2 and Liver Diseases
 Weight Gain Antibodies  >8 publications with INSIG2 and Weight Gain
 Weight Loss Antibodies  >7 publications with INSIG2 and Weight Loss
 Hypertension Antibodies  >5 publications with INSIG2 and Hypertension
 Hypertrophy Antibodies  >2 publications with INSIG2 and Hypertrophy
 Inflammation Antibodies  >2 publications with INSIG2 and Inflammation
 Congenital Abnormalities Antibodies  >2 publications with INSIG2 and Congenital Abnormalities

Organs/Tissues associated with anti-INSIG2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >35 publications with INSIG2 and Liver
 Blood Antibodies  >35 publications with INSIG2 and Blood
 Connective Tissue Antibodies  >12 publications with INSIG2 and Connective Tissue
 Muscle Antibodies  >7 publications with INSIG2 and Muscle
 Brain Antibodies  >6 publications with INSIG2 and Brain
 Bone Antibodies  >3 publications with INSIG2 and Bone
 Skin Antibodies  >3 publications with INSIG2 and Skin
 Intestine Antibodies  >3 publications with INSIG2 and Intestine
 Vascular Antibodies  >2 publications with INSIG2 and Vascular
 Mammary Gland Antibodies  >2 publications with INSIG2 and Mammary Gland
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