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CNOT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2575386

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation… More details

$265 / 0.06 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNOT1, Polyclonal Antibody
Full Product Name
CNOT1 Polyclonal Antibody
Product Gene Name
anti-CNOT1 antibody
Product Synonym Names
CNOT1; AD-005; CDC39; NOT1; NOT1H
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Storage: -20 degree C/One year. Avoid freeze/thaw cycles.
Molecular Weight
2376
OMIM
604917
3D Structure
ModBase 3D Structure for A5YKK6
Immunogen
Recombinant fusion protein of human CNOT1

Product Categories/Family for anti-CNOT1 antibody

Antibodies; Primary Antibodies; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CNOT1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CNOT1 antibody
WB: 1:200-1:2000
IF: 1:50-1:200

Western Blot (WB) of anti-CNOT1 antibody

Western blot analysis of extracts of various cell line using CNOT1 Polyclonal Antibody at 1:3000 dilution.
Rabbit Anti-CNOT1 Polyclonal Antibody – Cat# MBS2575386

Immunofluorescence (IF) of anti-CNOT1 antibody

Immunofluorescence analysis of L929 cells using CNOT1 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-CNOT1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2575386

Other Notes

Small volumes of anti-CNOT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNOT1 purchase

MBS2575386 is an antibody targeting CNOT1. Also known as CNOT1 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT1. It may not necessarily be applicable to this product.

NCBI GI #
166216086
NCBI GeneID
23019
NCBI Accession #
A5YKK6.2
UniProt Primary Accession #
A5YKK6
UniProt Secondary Accession #
Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0
UniProt Related Accession #
A5YKK6
NCBI Official Full Name
CCR4-NOT transcription complex subunit 1
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 1
NCBI Official Symbol
CNOT1
NCBI Official Synonym Symbols
NOT1; CDC39; NOT1H; AD-005
UniProt Protein Name
CCR4-NOT transcription complex subunit 1
UniProt Synonym Protein Names
CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1
Protein Family
CCR4-NOT transcription complex
UniProt Gene Name
CNOT1
UniProt Synonym Gene Names
CDC39; KIAA1007; NOT1; NOT1H; hNOT1
UniProt Entry Name
CNOT1_HUMAN
NCBI Protein Information
CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; adrenal gland protein AD-005; negative regulator of transcription subunit 1 homolog; NOT1 (negative regulator of transcription 1, yeast) homolog

UniProt Comments for CNOT1

NOT1: represses ligand-dependent transcriptional activation by oestrogen receptor (ER) alpha and several RXR heterodimers. Interacts with the ligand-binding domain of estrogen receptor-alpha in a hormone-dependent fashion.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; RNA-binding

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: nucleoplasm; peroxisomal membrane; extracellular space; membrane; cytosol; CCR4-NOT complex

Molecular Function: protein domain specific binding; protein binding; poly(A)-specific ribonuclease activity; retinoic acid receptor binding; estrogen receptor binding; protein complex scaffold

Biological Process: poly(A) tail shortening; negative regulation of retinoic acid receptor signaling pathway; transcription, DNA-dependent; negative regulation of translation; multicellular organismal development; gene expression; negative regulation of transcription from RNA polymerase II promoter; miRNA-mediated gene silencing; negative regulation of estrogen receptor signaling pathway; mRNA catabolic process, deadenylation-dependent decay
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Research Articles on CNOT1

1. CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CNOT1 antibody

 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with anti-CNOT1 antibody

 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >1 publications with CNOT1 and Heart Defects, Congenital
 Necrosis Antibodies  >1 publications with CNOT1 and Necrosis
 Kidney Diseases Antibodies  >1 publications with CNOT1 and Kidney Diseases

Organs/Tissues associated with anti-CNOT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with CNOT1 and Embryonic Tissue
 Brain Antibodies  >2 publications with CNOT1 and Brain
 Blood Antibodies  >1 publications with CNOT1 and Blood
 Heart Antibodies  >1 publications with CNOT1 and Heart
 Muscle Antibodies  >1 publications with CNOT1 and Muscle
 Uterus Antibodies  >1 publications with CNOT1 and Uterus
 Liver Antibodies  >1 publications with CNOT1 and Liver
 Testis Antibodies  >1 publications with CNOT1 and Testis
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