Mouse Anti-CD194/CCR4 Monoclonal Antibody – Cat# MBS2576157

Human peripheral blood lymphocytes are stained with FITC Anti-Human CD3 Antibody and PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody[L291H4] (Left). Lymphocytes are stained with FITC Anti-Human CD3 Antibody and PerCP/Cyanine5.5 Mouse IgG1, ? Isotype Control (Right).

CD194/CCR4 Antibody – Mouse Monoclonal

Name: CD194/CCR4 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2576157
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2576157

CD194, also known as CCR4, is CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are… More details

$180 / 20 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD194/CCR4, Monoclonal Antibody

Full Product Name

PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody [L291H4]

Product Gene Name

anti-CD194/CCR4 antibody

Product Synonym Names

CKR4; K5-5; CMKBR4; ChemR13; CC-CKR-4; MGC88293; HGCN:14099

Clonality

Monoclonal

Isotype

Mouse IgG1, kappa

Clone Number

L291H4

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid. Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Concentration

5uL/Test (lot specific)

Preparation and Storage

This product can be stored at 2-8 degree C for 12 months. Do not freeze.

Matching Pairs

Antibody: CD194/CCR4 (MBS2576157)
Isotype Control: IgG1 Clone #MOPC-21 (MBS2557738)

Molecular Weight

41,403 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (32993066..32996403). Location: 3p24

OMIM

604836

3D Structure

ModBase 3D Structure for P51679

Conjugation

PerCP/Cyanine5.5

Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent isuggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Product Categories/Family for anti-CD194/CCR4 antibody

Flow Cytometry Antibodies

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CD194/CCR4 antibody

Flow Cytometry (FC/FACS/FCM)

Other Notes

Small volumes of anti-CD194/CCR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD194/CCR4 purchase

MBS2576157 is an antibody targeting CD194/CCR4. Also known as PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody [L291H4]. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD194/CCR4. It may not necessarily be applicable to this product.

NCBI GI #

5031627

NCBI GeneID

1233

NCBI Accession #

NP_005499.1

UniProt Primary Accession #

P51679

UniProt Secondary Accession #

Q9ULY6; Q9ULY7

UniProt Related Accession #

P51679

GenBank Nucleotide #

NM_005508.4

NCBI Official Full Name

C-C chemokine receptor type 4

NCBI Official Synonym Full Names

chemokine (C-C motif) receptor 4

NCBI Official Symbol

CCR4

NCBI Official Synonym Symbols

CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099

UniProt Protein Name

C-C chemokine receptor type 4

UniProt Synonym Protein Names

K5-5

UniProt Gene Name

CCR4

UniProt Synonym Gene Names

CMKBR4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4

UniProt Entry Name

CCR4_HUMAN

NCBI Protein Information

C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4

NCBI Summary for CD194/CCR4

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

UniProt Comments for CD194/CCR4

CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p24

Cellular Component: cell soma; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: response to antibiotic; G-protein coupled receptor protein signaling pathway; response to radiation; elevation of cytosolic calcium ion concentration; positive regulation of positive chemotaxis; response to bacterium; neuron migration; immune response; chemotaxis; inflammatory response; tolerance induction

Research Articles on CD194/CCR4

1. lymph node metastasis of CCR4(+) HNSCC is promoted by CCL22 in an autocrine or M2-like macrophage-dependent paracrine manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD194/CCR4 antibody

Reference Product	PubMed Publications
CCL17 antibody	>226 publications with CD194/CCR4 and CCL17
CCL22 antibody	>198 publications with CD194/CCR4 and CCL22
CCL5 antibody	>83 publications with CD194/CCR4 and CCL5
CCL3 antibody	>43 publications with CD194/CCR4 and CCL3
ADRBK1 antibody	>2 publications with CD194/CCR4 and ADRBK1
ADRBK2 antibody	>1 publications with CD194/CCR4 and ADRBK2

Pathways associated with anti-CD194/CCR4 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CD194/CCR4 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>239 publications with CD194/CCR4 and Inflammation
Neoplasms Antibodies	>187 publications with CD194/CCR4 and Neoplasms
Lung Diseases Antibodies	>119 publications with CD194/CCR4 and Lung Diseases
Necrosis Antibodies	>77 publications with CD194/CCR4 and Necrosis
Drug Hypersensitivity Antibodies	>33 publications with CD194/CCR4 and Drug Hypersensitivity
Carcinoma Antibodies	>32 publications with CD194/CCR4 and Carcinoma
Fibrosis Antibodies	>26 publications with CD194/CCR4 and Fibrosis
Heart Diseases Antibodies	>16 publications with CD194/CCR4 and Heart Diseases
Neoplasms, Experimental Antibodies	>16 publications with CD194/CCR4 and Neoplasms, Experimental
Liver Diseases Antibodies	>16 publications with CD194/CCR4 and Liver Diseases

Organs/Tissues associated with anti-CD194/CCR4 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>759 publications with CD194/CCR4 and Blood
Thymus Antibodies	>148 publications with CD194/CCR4 and Thymus
Lung Antibodies	>128 publications with CD194/CCR4 and Lung
Brain Antibodies	>25 publications with CD194/CCR4 and Brain
Adipose Tissue Antibodies	>7 publications with CD194/CCR4 and Adipose Tissue