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CD249 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2579057

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. More details

$150 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD249, Monoclonal Antibody
Full Product Name
Purified Anti-Mouse CD249 (Ly-51) Antibody [6C3]
Product Gene Name
anti-CD249 antibody
Clonality
Monoclonal
Isotype
Rat IgG2a, kappa
Clone Number
6C3
Host
Rat
Species Reactivity
Mouse
Form/Format
Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Concentration
>=1mg/mL (lot specific)
Preparation and Storage
Store at 4 degree C valid for 12 months or -20 degree C valid for long term storage, avoid freeze/thaw cycles.
Molecular Weight
107,956 Da
3D Structure
ModBase 3D Structure for P16406

Product Categories/Family for anti-CD249 antibody

FC Purified Antibodies; Flow Cytometry Antibodies
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD249 antibody
Flow Cytometry (FC/FACS/FCM)

Other Notes

Small volumes of anti-CD249 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD249 purchase

MBS2579057 is an antibody targeting CD249. Also known as Purified Anti-Mouse CD249 (Ly-51) Antibody [6C3]. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD249. It may not necessarily be applicable to this product.

NCBI GI #
6679653
NCBI GeneID
13809
NCBI Accession #
NP_031960.1
UniProt Primary Accession #
P16406
UniProt Related Accession #
P16406
GenBank Nucleotide #
NM_007934.3
NCBI Official Full Name
glutamyl aminopeptidase
NCBI Official Synonym Full Names
glutamyl aminopeptidase
NCBI Official Symbol
Enpep
NCBI Official Synonym Symbols
APA; Ly51; Ly-51; Bp-1/6C3; 6030431M22Rik
UniProt Protein Name
Glutamyl aminopeptidase
UniProt Synonym Protein Names
Aminopeptidase A; AP-A; BP-1/6C3 antigen; CD_antigen: CD249
UniProt Gene Name
Enpep
UniProt Synonym Gene Names
EAP; AP-A
UniProt Entry Name
AMPE_MOUSE
NCBI Protein Information
glutamyl aminopeptidase

UniProt Comments for CD249

ENPEP: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells. Belongs to the peptidase M1 family.

Protein type: Protease; EC 3.4.11.7; Membrane protein, integral

Cellular Component: apical part of cell; apical plasma membrane; brush border; cytoplasmic vesicle; external side of plasma membrane; integral to membrane; lysosomal membrane; membrane; plasma membrane; vesicle membrane

Molecular Function: aminopeptidase activity; hydrolase activity; metal ion binding; metallopeptidase activity; peptidase activity; peptide binding; zinc ion binding

Biological Process: angiogenesis; aromatic compound metabolic process; cell migration; cell proliferation; peptide catabolic process; proteolysis; regulation of blood pressure; regulation of systemic arterial blood pressure by renin-angiotensin
Show more

Research Articles on CD249

1. de-regulation of both PITX2 and ENPEP could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD249 antibody

 Reference Product  PubMed Publications
 Anpep antibody  >1 publications with CD249 and Anpep

Pathways associated with anti-CD249 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram

Diseases associated with anti-CD249 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with CD249 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >2 publications with CD249 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >2 publications with CD249 and Kidney Diseases
 Acute Kidney Injury Antibodies  >1 publications with CD249 and Acute Kidney Injury
 Liver Diseases Antibodies  >1 publications with CD249 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with CD249 and Fatty Liver
 Fibrosis Antibodies  >1 publications with CD249 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with CD249 and Carcinoma, Hepatocellular
 Congenital Abnormalities Antibodies  >1 publications with CD249 and Congenital Abnormalities
 Liver Neoplasms Antibodies  >1 publications with CD249 and Liver Neoplasms

Organs/Tissues associated with anti-CD249 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with CD249 and Kidney
 Liver Antibodies  >4 publications with CD249 and Liver
 Heart Antibodies  >3 publications with CD249 and Heart
 Thymus Antibodies  >2 publications with CD249 and Thymus
 Embryonic Tissue Antibodies  >2 publications with CD249 and Embryonic Tissue
 Spleen Antibodies  >1 publications with CD249 and Spleen
 Pancreas Antibodies  >1 publications with CD249 and Pancreas
 Lung Antibodies  >1 publications with CD249 and Lung
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