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MMP-1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2579147

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-1 (interstitial collagenase), can degrade a broad range of substrates including types… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MMP-1, Polyclonal Antibody
Full Product Name
MMP-1 Polyclonal Antibody
Product Gene Name
anti-MMP-1 antibody
Product Synonym Names
MMP-1; CLG
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
Purity/Purification
Antigen Affinity Purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C Valid for 12 months. Avoid freeze/thaw cycles.
Molecular Weight
54,007 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (102660641..102668966, complement). Location: 11q22.3
OMIM
120353
3D Structure
ModBase 3D Structure for P03956
Immunogen
Recombinant Human MMP-1 protein expressed by E coli

Product Categories/Family for anti-MMP-1 antibody

Polyclonal Antibodies; Primary Antibodies; Polyclonal Antibodies; Cancer; Cell Biology; Cardiovascular; Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MMP-1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-MMP-1 antibody
IHC: 1:300-1:600

Immunohistochemistry (IHC) of anti-MMP-1 antibody

Immunohistochemistry of paraffin-embedded Human lung cancer using MMP-1 Polyclonal Antibody at dilution of 1:600
Rabbit Anti-MMP-1 Polyclonal Antibody – Cat# MBS2579147

Immunohistochemistry (IHC) of anti-MMP-1 antibody

Immunohistochemistry of paraffin-embedded Human cervical cancer using MMP-1 Polyclonal Antibody at dilution of 1:600
Rabbit Anti-MMP-1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2579147

Other Notes

Small volumes of anti-MMP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP-1 purchase

MBS2579147 is an antibody targeting MMP-1. Also known as MMP-1 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-1. It may not necessarily be applicable to this product.

NCBI GI #
4505215
NCBI GeneID
4312
NCBI Accession #
NP_002412.1
UniProt Primary Accession #
P03956
UniProt Secondary Accession #
P08156
UniProt Related Accession #
P03956
GenBank Nucleotide #
NM_002421.3
NCBI Official Full Name
interstitial collagenase isoform 1 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 1 (interstitial collagenase)
NCBI Official Symbol
MMP1
NCBI Official Synonym Symbols
CLG; CLGN
UniProt Protein Name
Interstitial collagenase
UniProt Synonym Protein Names
Fibroblast collagenase; Matrix metalloproteinase-1
Protein Family
Interstitial collagenase
UniProt Gene Name
MMP1
UniProt Synonym Gene Names
CLG; MMP-1
UniProt Entry Name
MMP1_HUMAN
NCBI Protein Information
interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1

NCBI Summary for MMP-1

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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UniProt Comments for MMP-1

MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Belongs to the peptidase M10A family.

Protein type: Protease; Secreted, signal peptide; EC 3.4.24.7; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding

Biological Process: positive regulation of protein oligomerization; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cellular protein metabolic process; viral reproduction; blood coagulation; proteolysis; leukocyte migration

Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive
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Research Articles on MMP-1

1. the increase of MMP-1 and MMP-9 expression and low of TIMP-1 and TIMP-2 expression makes the main contribution to the destructive (invasive) potential of SCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP-1 antibody

 Reference Product  PubMed Publications
 TIMP1 antibody  >100 publications with MMP-1 and TIMP1
 MMP7 antibody  >46 publications with MMP-1 and MMP7
 CCL2 antibody  >10 publications with MMP-1 and CCL2
 COL2A1 antibody  >7 publications with MMP-1 and COL2A1
 TNFSF11 antibody  >7 publications with MMP-1 and TNFSF11
 CD44 antibody  >4 publications with MMP-1 and CD44
 BSG antibody  >4 publications with MMP-1 and BSG
 ACAN antibody  >4 publications with MMP-1 and ACAN
 ITGA2 antibody  >3 publications with MMP-1 and ITGA2
 IGFBP3 antibody  >2 publications with MMP-1 and IGFBP3

Pathways associated with anti-MMP-1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram

Diseases associated with anti-MMP-1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >231 publications with MMP-1 and Neoplasms
 Inflammation Antibodies  >89 publications with MMP-1 and Inflammation
 Cardiovascular Diseases Antibodies  >68 publications with MMP-1 and Cardiovascular Diseases
 Neoplasm Invasiveness Antibodies  >65 publications with MMP-1 and Neoplasm Invasiveness
 Lung Diseases Antibodies  >63 publications with MMP-1 and Lung Diseases
 Necrosis Antibodies  >59 publications with MMP-1 and Necrosis
 Neoplasm Metastasis Antibodies  >52 publications with MMP-1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >48 publications with MMP-1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >36 publications with MMP-1 and Lung Neoplasms
 Heart Diseases Antibodies  >29 publications with MMP-1 and Heart Diseases

Organs/Tissues associated with anti-MMP-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >111 publications with MMP-1 and Blood
 Skin Antibodies  >105 publications with MMP-1 and Skin
 Lung Antibodies  >84 publications with MMP-1 and Lung
 Vascular Antibodies  >74 publications with MMP-1 and Vascular
 Bone Antibodies  >71 publications with MMP-1 and Bone
 Connective Tissue Antibodies  >65 publications with MMP-1 and Connective Tissue
 Muscle Antibodies  >38 publications with MMP-1 and Muscle
 Liver Antibodies  >26 publications with MMP-1 and Liver
 Embryonic Tissue Antibodies  >26 publications with MMP-1 and Embryonic Tissue
 Eye Antibodies  >24 publications with MMP-1 and Eye
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