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CK17 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2579960

Cytokeratin 17 (CK17), with a molecular weight of 46 kDa, which is expressed in basal cells of stratified and pseudostratified epithelium. Cytokeratin 17 Monoclonal is mainly used for the judging of squamous cell carcinoma of the lung, cervix and mouth. More details

$410 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CK17, Monoclonal Antibody
Full Product Name
CK17 Monoclonal Antibody
Product Gene Name
anti-CK17 antibody
Clonality
Monoclonal
Clone Number
YN00686m
Host
Mouse
Species Reactivity
Human
Preparation and Storage
The concentrated should be stored at -20 degree C protecting from light,Valid for 12 months.
Molecular Weight
48,106 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (39775692..39780882, complement). Location: 17q21.2
OMIM
148069
3D Structure
ModBase 3D Structure for Q04695

Product Categories/Family for anti-CK17 antibody

Pathology Antibodies; Primary Antibodies; Concentrated Antibodies
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CK17 antibody
Immunohistochemistry-Paraffin (IHC-P)

Other Notes

Small volumes of anti-CK17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CK17 purchase

MBS2579960 is an antibody targeting CK17. Also known as CK17 Monoclonal Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CK17. It may not necessarily be applicable to this product.

NCBI GI #
4557701
NCBI GeneID
3872
NCBI Accession #
NP_000413.1
UniProt Primary Accession #
Q04695
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2
UniProt Related Accession #
Q04695
GenBank Nucleotide #
NM_000422.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
UniProt Entry Name
K1C17_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 17; 39.1; CK-17; keratin-17; cytokeratin-17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4

NCBI Summary for CK17

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

UniProt Comments for CK17

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding

Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth

Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
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Research Articles on CK17

1. We identified a known mutation in the KRT17 gene in a family with steatocystoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CK17 antibody

 Reference Product  PubMed Publications
 KRT6A antibody  >17 publications with CK17 and KRT6A
 KRT7 antibody  >1 publications with CK17 and KRT7

Pathways associated with anti-CK17 antibody

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-CK17 antibody

 Disease Name  Pubmed Publications
 Pachyonychia congenita Jackson Lawler type Antibodies  >20 publications with CK17 and Pachyonychia congenita Jackson Lawler type
 Neoplasms Antibodies  >19 publications with CK17 and Neoplasms
 Adenocarcinoma Antibodies  >7 publications with CK17 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >7 publications with CK17 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with CK17 and Breast Neoplasms
 Pain Antibodies  >4 publications with CK17 and Pain
 Skin Neoplasms Antibodies  >3 publications with CK17 and Skin Neoplasms
 Carcinoma, Basal Cell Antibodies  >2 publications with CK17 and Carcinoma, Basal Cell
 Esophageal Squamous Cell Carcinoma Antibodies  >2 publications with CK17 and Esophageal Squamous Cell Carcinoma
 Precancerous Conditions Antibodies  >1 publications with CK17 and Precancerous Conditions

Organs/Tissues associated with anti-CK17 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with CK17 and Skin
 Mouth Antibodies  >3 publications with CK17 and Mouth
 Lymph Antibodies  >2 publications with CK17 and Lymph
 Mammary Gland Antibodies  >2 publications with CK17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with CK17 and Lymph Node
 Intestine Antibodies  >1 publications with CK17 and Intestine
 Bladder Antibodies  >1 publications with CK17 and Bladder
 Prostate Antibodies  >1 publications with CK17 and Prostate
 Muscle Antibodies  >1 publications with CK17 and Muscle
 Pancreas Antibodies  >1 publications with CK17 and Pancreas
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