Cofilin 2, Muscle (CFL2) ELISA Kit for Cavy

Name: Cavy CFL2 ELISA Kit; Cofilin 2, Muscle; MyBioSource
Brand: MyBioSource
SKU: MBS026126
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS026126

MBS026126 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cofilin 2, Muscle (CFL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Cofilin 2, Muscle (CFL2), ELISA Kit

Full Product Name

Cavy Cofilin 2, Muscle ELISA Kit

Product Gene Name

CFL2 elisa kit

Species Reactivity

Cavy

Assay Type

Sandwich

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

18,737 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (35179588..35184029, complement). Location: 14q12

OMIM

601443

3D Structure

ModBase 3D Structure for Q9Y281

Other Notes

Small volumes of CFL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CFL2. It may not necessarily be applicable to this product.

NCBI GI #

343887344

NCBI GeneID

1073

NCBI Accession #

NP_001230574.1

UniProt Primary Accession #

Q9Y281

UniProt Secondary Accession #

G3V5P4

UniProt Related Accession #

Q9Y281

GenBank Nucleotide #

NM_001243645.1

NCBI Official Full Name

cofilin-2 isoform 2

NCBI Official Synonym Full Names

cofilin 2 (muscle)

NCBI Official Symbol

CFL2

NCBI Official Synonym Symbols

NEM7

UniProt Protein Name

Cofilin-2

UniProt Synonym Protein Names

Cofilin, muscle isoform

Protein Family

Cofilin

UniProt Gene Name

CFL2

UniProt Entry Name

COF2_HUMAN

NCBI Protein Information

cofilin-2; cofilin, muscle isoform; nemaline myopathy type 7

NCBI Summary for CFL2

This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

UniProt Comments for CFL2

Cofilin-2: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.

Protein type: Cytoskeletal; Nuclear receptor co-regulator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: I band; extracellular space; nuclear matrix; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: muscle maintenance; actin filament depolymerization; positive regulation of actin filament depolymerization; sarcomere organization

Disease: Nemaline Myopathy 7

Research Articles on CFL2

1. Studies indicate that cofilin binds actin stoichiometrically - one cofilin molecule per actin filament subunit.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CFL2 elisa kit

Reference Product	PubMed Publications
LIMK1 elisa kit	>2 publications with CFL2 and LIMK1
RHOA elisa kit	>1 publications with CFL2 and RHOA
LIMK2 elisa kit	>1 publications with CFL2 and LIMK2

Pathways associated with CFL2 elisa kit

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Caspase Cascade In Apoptosis Pathway antibodies	Caspase Cascade In Apoptosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
G13 Signaling Pathway antibodies	G13 Signaling Pathway Diagram
Leptin Signaling Pathway antibodies	Leptin Signaling Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Regulation Of Actin Cytoskeleton Pathway antibodies	Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with CFL2 elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with CFL2 and Neoplasms
Congenital Abnormalities Antibodies	>2 publications with CFL2 and Congenital Abnormalities
Disease Models, Animal Antibodies	>2 publications with CFL2 and Disease Models, Animal
Nemaline Myopathy 7 Antibodies	>2 publications with CFL2 and Nemaline Myopathy 7
Nervous System Malformations Antibodies	>1 publications with CFL2 and Nervous System Malformations
Carcinoma Antibodies	>1 publications with CFL2 and Carcinoma
Neural Tube Defects Antibodies	>1 publications with CFL2 and Neural Tube Defects
Adenocarcinoma Antibodies	>1 publications with CFL2 and Adenocarcinoma
Hyperplasia Antibodies	>1 publications with CFL2 and Hyperplasia

Organs/Tissues associated with CFL2 elisa kit

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>19 publications with CFL2 and Muscle
Blood Antibodies	>3 publications with CFL2 and Blood
Vascular Antibodies	>3 publications with CFL2 and Vascular
Heart Antibodies	>3 publications with CFL2 and Heart
Embryonic Tissue Antibodies	>2 publications with CFL2 and Embryonic Tissue
Adipose Tissue Antibodies	>1 publications with CFL2 and Adipose Tissue
Connective Tissue Antibodies	>1 publications with CFL2 and Connective Tissue
Testis Antibodies	>1 publications with CFL2 and Testis
Kidney Antibodies	>1 publications with CFL2 and Kidney
Brain Antibodies	>1 publications with CFL2 and Brain