Anti-Q-Ab (Q-Ab) ELISA Kit for Porcine

ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cell projection; plasma membrane; extracellular region; nucleus

Molecular Function: protein binding; metal ion binding; receptor tyrosine kinase binding; vascular endothelial growth factor receptor binding

Biological Process: negative regulation of positive chemotaxis; Tie receptor signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; multicellular organismal development; blood vessel morphogenesis; blood vessel remodeling; hemopoiesis; angiogenesis; cell differentiation; negative regulation of blood vessel endothelial cell migration; regulation of angiogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; endoderm development