Endothelial Nitric Oxide Synthase 3 (eNOS-3) ELISA Kit for Guinea Pig

eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.

Protein type: Oxidoreductase; EC 1.14.13.39; Amino Acid Metabolism - arginine and proline

Cellular Component: Golgi apparatus; mitochondrion; caveola; vesicle membrane; cytosol; lipid raft; cytoskeleton; apical part of cell; cytoplasm; nucleolus; plasma membrane; nucleus; sarcolemma

Molecular Function: actin monomer binding; FAD binding; nitric-oxide synthase activity; beta-catenin binding; Hsp90 protein binding; actin binding; calmodulin binding; protein binding; NADPH-hemoprotein reductase activity; FMN binding; cadherin binding; iron ion binding; heme binding; NADP binding; nitric-oxide synthase binding

Biological Process: response to peptide hormone stimulus; response to metal ion; regulation of systemic arterial blood pressure by endothelin; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; negative regulation of potassium ion transport; negative regulation of muscle hyperplasia; response to lipopolysaccharide; female pregnancy; signal transduction; positive regulation of vasodilation; response to organic cyclic substance; response to estradiol stimulus; negative regulation of cell proliferation; negative regulation of hydrolase activity; regulation of the force of heart contraction by chemical signal; lipopolysaccharide-mediated signaling pathway; response to lipoprotein stimulus; negative regulation of blood pressure; response to axon injury; angiogenesis; regulation of blood vessel size; nitric oxide biosynthetic process; response to fructose stimulus; aging; response to corticosterone stimulus; response to drug; negative regulation of calcium ion transport; in utero embryonic development; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; response to amino acid stimulus; ovulation from ovarian follicle; positive regulation of angiogenesis; response to ethanol; response to hyperoxia; response to mechanical stimulus; retina development in camera-type eye; response to cytokine stimulus; response to lead ion; response to hypoxia; endothelial cell migration; arginine catabolic process; blood vessel remodeling; response to activity; nitric oxide mediated signal transduction; lung development; smooth muscle hyperplasia