RBM5 Antibody – Rabbit

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

RBM5: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. Belongs to the RBM5/RBM10 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; RNA splicing; C2H2-type zinc finger protein; RNA processing; Apoptosis; RNA-binding

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: nucleoplasm; spliceosome; nucleus

Molecular Function: mRNA binding; protein binding; DNA binding; zinc ion binding; RNA binding; nucleotide binding

Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; negative regulation of cell proliferation; apoptosis; positive regulation of apoptosis; RNA splicing; spliceosome assembly; gene expression; regulation of alternative nuclear mRNA splicing, via spliceosome