PLD2 Antibody – Rabbit Polyclonal

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PLD2: a phosphatidylcholine-specific phospholipase D. Catalyzes the hydrolysis of PC to produce phosphatidic acid and choline. Activated as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. May function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. Enriched in caveolae; may be involved in MEK/ERK signaling cascades induced by the VEGF/VEGFR-2/PKC-delta pathway in endothelial cells. Three alternatively spliced isoforms have been described.

Protein type: EC 3.1.4.4; Motility/polarity/chemotaxis; Lipid Metabolism - glycerophospholipid; Phospholipase; Lipid Metabolism - ether lipid

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: endoplasmic reticulum membrane; brush border membrane; plasma membrane

Molecular Function: protein binding; phospholipase D activity; phosphoinositide binding

Biological Process: G-protein coupled receptor internalization; phosphatidylglycerol biosynthetic process; phospholipid metabolic process; small GTPase mediated signal transduction; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; innate immune response; cytoskeleton organization and biogenesis; lipid catabolic process