Soluble Retinoid X Receptor (RXR) ELISA Kit for Rabbit

SREBP-1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, multi-pass; Membrane protein, integral; DNA-binding

Cellular Component: Golgi apparatus; protein complex; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; cytoplasm; integral to membrane; cytoplasmic vesicle; nucleus

Molecular Function: protein dimerization activity; protein binding; sterol response element binding; DNA binding; sequence-specific DNA binding; protein complex binding; chromatin binding; protein kinase binding; transcription factor activity

Biological Process: steroid metabolic process; cholesterol metabolic process; positive regulation of fatty acid biosynthetic process; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; lipid biosynthetic process; positive regulation of cholesterol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; negative regulation of insulin secretion; positive regulation of histone deacetylation; regulation of transcription, DNA-dependent; chemical signal regulation of heart rate; regulation of fatty acid metabolic process; insulin receptor signaling pathway; response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; regulation of insulin secretion