Activated CDC42 Kinase 1 (TNK2) ELISA Kit for Rat

Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.

Protein type: Ack family; EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: adherens junction; axon; cell soma; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle membrane; dendrite; endosome; extrinsic component of cytoplasmic side of plasma membrane; growth cone; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; epidermal growth factor receptor binding; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; receptor binding; ubiquitin protein ligase binding; WW domain binding

Biological Process: cell differentiation; cell migration; endocytosis; innate immune response; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell proliferation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway