Casein Kinase II Subunit Beta (CSNK2B) ELISA Kit for Mouse

This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 17 B1|17 18.59 cM

Cellular Component: cell projection; chromatin; cilium; cytoplasm; extracellular exosome; nuclear matrix; nucleus; PcG protein complex; plasma membrane; protein kinase CK2 complex

Molecular Function: chromatin binding; identical protein binding; metal ion binding; protein binding; protein domain specific binding; protein kinase regulator activity; protein serine/threonine kinase activity; receptor binding; ribonucleoprotein complex binding; transcription factor binding

Biological Process: adiponectin-activated signaling pathway; endothelial tube morphogenesis; negative regulation of blood vessel endothelial cell migration; peptidyl-threonine phosphorylation; positive regulation of activin receptor signaling pathway; positive regulation of pathway-restricted SMAD protein phosphorylation; Wnt signaling pathway