Probable ATP-Dependent RNA Helicase DDX5 (DDX5) ELISA Kit for Human

This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

DDX5: a putative ATP-dependent RNA helicase. A proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Belongs to the DEAD box helicase family. DDX5/DDX17 subfamily. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: catalytic step 2 spliceosome; cytoplasm; extracellular exosome; extracellular matrix; intracellular ribonucleoprotein complex; membrane; nucleolus; nucleoplasm; nucleus; SMAD protein complex

Molecular Function: androgen receptor binding; ATP binding; ATP-dependent RNA helicase activity; calcium-dependent protein binding; calmodulin binding; enzyme binding; mRNA 3'-UTR binding; promoter-specific chromatin binding; protein binding; R-SMAD binding; ribonucleoprotein complex binding; RNA binding; RNA helicase activity; SMAD binding

Biological Process: alternative mRNA splicing, via spliceosome; androgen receptor signaling pathway; BMP signaling pathway; cell growth; epithelial to mesenchymal transition; intracellular estrogen receptor signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA splicing, via spliceosome; mRNA transcription; myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; nuclear-transcribed mRNA catabolic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of alternative mRNA splicing, via spliceosome; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; regulation of transcription from RNA polymerase II promoter; regulation of viral genome replication; rhythmic process; RNA secondary structure unwinding