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Glycoprotein 130 (GP130) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS280898

Background: Glycoprotein 130 is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130… More details

$545 / 48 Tests +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glycoprotein 130 (GP130), ELISA Kit
Full Product Name
Human Glycoprotein 130 (GP130) ELISA Kit
Product Gene Name
GP130 elisa kit
Species Reactivity
Human
Assay Type
Quantitative Sandwich
Samples
Serum, plasma, tissue homogenates and other biological fluids
Detection Range
0.625 ng/mL - 40 ng/mL
Sensitivity
0.31 ng/mL (mean of 6 independent assays)
Specificity
This assay has high sensitivity and excellent specificity for detection of Human GP130. No significant cross-reactivity or interference between Human GP130 and analogues was observed.
Preparation and Storage
Store at 2-8 degree C.
Inter-assay Precision
Inter-assay Precision (Precision between assays) Three samples of known concentration were tested in forty separate assays to assess inter-assay precision. CV (%) = SD/meanX100. Inter-Assay: CV<12%
Intra-assay Precision
Intra-assay Precision (Precision within an assay) Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision. Intra-Assay: CV<8%
Molecular Weight
102,451 Da
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GP130 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GP130 purchase

MBS280898 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glycoprotein 130 (GP130) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GP130. The ELISA analytical biochemical technique of the MBS280898 kit is based on GP130 antibody-GP130 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GP130 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GP130. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for GP130. It may not necessarily be applicable to this product.

NCBI GI #
193592
NCBI GeneID
16195
NCBI Accession #
AAA37723.1
UniProt Secondary Accession #
G5E8D2
UniProt Related Accession #
Q00560
NCBI Official Full Name
glycoprotein 130
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Symbol
Il6st
NCBI Official Synonym Symbols
CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
UniProt Protein Name
Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names
Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
Protein Family
Interleukin-6 receptor
UniProt Gene Name
Il6st
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
UniProt Entry Name
IL6RB_MOUSE
NCBI Protein Information
interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha

UniProt Comments for GP130

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; integral to membrane; interleukin-6 receptor complex; cytosol; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 receptor binding; interleukin-6 binding; protein heterodimerization activity; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: glycogen metabolic process; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; signal transduction; positive regulation of smooth muscle cell migration; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; response to cytokine stimulus; reduction of cytosolic calcium ion concentration; positive regulation of cell proliferation; positive regulation of T cell proliferation; triacylglycerol mobilization; positive regulation of astrocyte differentiation
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Research Articles on GP130

1. study concludes that in a setting of islet inflammation and pathophysiology modeling type 2 diabetes, activation of alpha-cell gp130 receptor signaling has deleterious effects on alpha-cell function, promoting hyperglycemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GP130 elisa kit

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Signaling Pathway antibodies  Interleukin-6 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with GP130 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >116 publications with GP130 and Inflammation
 Cardiovascular Diseases Antibodies  >102 publications with GP130 and Cardiovascular Diseases
 Carcinoma Antibodies  >59 publications with GP130 and Carcinoma
 Disease Models, Animal Antibodies  >52 publications with GP130 and Disease Models, Animal
 Nervous System Diseases Antibodies  >51 publications with GP130 and Nervous System Diseases
 Heart Diseases Antibodies  >48 publications with GP130 and Heart Diseases
 Necrosis Antibodies  >44 publications with GP130 and Necrosis
 Liver Diseases Antibodies  >38 publications with GP130 and Liver Diseases
 Hypertrophy Antibodies  >31 publications with GP130 and Hypertrophy
 Arthritis, Rheumatoid Antibodies  >25 publications with GP130 and Arthritis, Rheumatoid

Organs/Tissues associated with GP130 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >212 publications with GP130 and Blood
 Liver Antibodies  >87 publications with GP130 and Liver
 Bone Antibodies  >80 publications with GP130 and Bone
 Brain Antibodies  >78 publications with GP130 and Brain
 Heart Antibodies  >72 publications with GP130 and Heart
 Bone Marrow Antibodies  >57 publications with GP130 and Bone Marrow
 Embryonic Tissue Antibodies  >33 publications with GP130 and Embryonic Tissue
 Lung Antibodies  >32 publications with GP130 and Lung
 Kidney Antibodies  >18 publications with GP130 and Kidney
 Joint Antibodies  >17 publications with GP130 and Joint
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