PRKC Apoptosis WT1 Regulator (PAWR) ELISA Kit for Human

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 12q21.2

Cellular Component: actin filament; cytoplasm; nuclear chromatin; nucleus

Molecular Function: actin binding; enzyme binding; leucine zipper domain binding; protein binding; transcription corepressor activity

Biological Process: actin filament bundle formation; apoptosis; interleukin-2 biosynthetic process; negative regulation of B cell proliferation; negative regulation of fibroblast proliferation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptosis; positive regulation of cellular senescence; positive regulation of gene expression; positive regulation of hydrogen peroxide-mediated programmed cell death; transcription, DNA-dependent