Phospholemman (FXYD1) ELISA Kit for Human

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]

PLM: a protein of the FXYD family of small ion transport regulators or channels. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May have a functional role in muscle contraction. Major plasma membrane substrate for PKA and PKC in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation.Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining.

Protein type: Cell surface; Channel, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: apical plasma membrane; caveola; integral component of plasma membrane; intercalated disc; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule

Molecular Function: chloride channel activity; ion channel binding; sodium channel regulator activity

Biological Process: chloride transport; muscle contraction; negative regulation of protein glutathionylation; potassium ion transport; regulation of cardiac muscle cell membrane potential; regulation of heart contraction; regulation of sodium ion transmembrane transporter activity; sodium ion transport