• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Potassium Voltage-Gated Channel Subfamily D Member 2 (KCND2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS281408

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate KCND2 in samples. An antibody specific for KCND2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKCND2 present is bound by the… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Potassium voltage-gated channel subfamily D member 2 (KCND2), ELISA Kit
Full Product Name
Human Potassium voltage-gated channel subfamily D member 2 (KCND2) ELISA Kit
Product Gene Name
KCND2 elisa kit
Species Reactivity
Human
Assay Type
Sandwich
Samples
Serum, Plasma, Other biological fluids
Specificity
This assay has high sensitivity and excellent specificity for detection of Human KCND2. No significant cross-reactivity or interference between Human KCND2 and analogues was observed.
Preparation and Storage
Store at 2-8 degree C.
Molecular Weight
70,537 Da
OMIM
AF121104 mRNA
3D Structure
ModBase 3D Structure for Q9NZV8
Sample Volume
1-200 uL
Precision
Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
Detection Wavelength
450 nm
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KCND2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCND2 purchase

MBS281408 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium voltage-gated channel subfamily D member 2 (KCND2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCND2. The ELISA analytical biochemical technique of the MBS281408 kit is based on KCND2 antibody-KCND2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCND2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCND2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for KCND2. It may not necessarily be applicable to this product.

NCBI GI #
9789987
NCBI GeneID
3751
NCBI Accession #
NP_036413.1
UniProt Primary Accession #
Q9NZV8
UniProt Secondary Accession #
O95012; O95021; Q2TBD3; Q9UBY7; Q9UN98; Q9UNH9
UniProt Related Accession #
Q9NZV8
GenBank Nucleotide #
NM_012281.2
NCBI Official Full Name
potassium voltage-gated channel subfamily D member 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily D member 2
NCBI Official Symbol
KCND2
NCBI Official Synonym Symbols
RK5; KV4.2
UniProt Protein Name
Potassium voltage-gated channel subfamily D member 2
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv4.2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCND2
UniProt Synonym Gene Names
KIAA1044
NCBI Protein Information
potassium voltage-gated channel subfamily D member 2

NCBI Summary for KCND2

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for KCND2

Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q31.31

Cellular Component: cell junction; dendritic spine; integral component of plasma membrane; intrinsic component of plasma membrane; perikaryon; plasma membrane; postsynaptic membrane; voltage-gated potassium channel complex

Molecular Function: A-type (transient outward) potassium channel activity; metal ion binding; protein binding; voltage-gated potassium channel activity

Biological Process: cellular response to hypoxia; generation of action potential; locomotor rhythm; potassium ion transmembrane transport; protein homooligomerization; regulation of action potential; regulation of ion transmembrane transport; sensory perception of pain; synaptic transmission
Show more

Research Articles on KCND2

1. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KCND2 elisa kit

 Reference Product  PubMed Publications
 KCNIP2 elisa kit  >16 publications with KCND2 and KCNIP2
 KCNIP1 elisa kit  >11 publications with KCND2 and KCNIP1
 KCNIP4 elisa kit  >4 publications with KCND2 and KCNIP4
 KCNH2 elisa kit  >2 publications with KCND2 and KCNH2
 IRX5 elisa kit  >2 publications with KCND2 and IRX5
 KCNC1 elisa kit  >1 publications with KCND2 and KCNC1
 KCNAB2 elisa kit  >1 publications with KCND2 and KCNAB2

Pathways associated with KCND2 elisa kit

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with KCND2 elisa kit

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >22 publications with KCND2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >21 publications with KCND2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >13 publications with KCND2 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >10 publications with KCND2 and Hypertrophy
 Disease Models, Animal Antibodies  >9 publications with KCND2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >8 publications with KCND2 and Nervous System Diseases
 Heart Failure Antibodies  >5 publications with KCND2 and Heart Failure
 Cardiomegaly Antibodies  >5 publications with KCND2 and Cardiomegaly
 Hypertension Antibodies  >5 publications with KCND2 and Hypertension
 Seizures Antibodies  >4 publications with KCND2 and Seizures

Organs/Tissues associated with KCND2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >44 publications with KCND2 and Brain
 Kidney Antibodies  >11 publications with KCND2 and Kidney
 Embryonic Tissue Antibodies  >7 publications with KCND2 and Embryonic Tissue
 Ovary Antibodies  >4 publications with KCND2 and Ovary
 Vascular Antibodies  >3 publications with KCND2 and Vascular
 Connective Tissue Antibodies  >1 publications with KCND2 and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000