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Potassium Voltage-Gated Channel Subfamily B Member 2 (KCNB2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS282120

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate KCNB2 in samples. An antibody specific for KCNB2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKCNB2 present is bound by the… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Potassium voltage-gated channel subfamily B member 2 (KCNB2), ELISA Kit
Full Product Name
Human Potassium voltage-gated channel subfamily B member 2 (KCNB2) ELISA Kit
Product Gene Name
KCNB2 elisa kit
Species Reactivity
Human
Assay Type
Sandwich
Samples
Serum, Plasma, Other biological fluids
Specificity
This assay has high sensitivity and excellent specificity for detection of Human KCNB2. No significant cross-reactivity or interference between Human KCNB2 and analogues was observed.
Preparation and Storage
Store at 2-8 degree C.
Molecular Weight
102,563 Da
OMIM
AF450111 mRNA
3D Structure
ModBase 3D Structure for Q92953
Sample Volume
1-200 uL
Precision
Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
Detection Wavelength
450 nm
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KCNB2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNB2 purchase

MBS282120 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium voltage-gated channel subfamily B member 2 (KCNB2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNB2. The ELISA analytical biochemical technique of the MBS282120 kit is based on KCNB2 antibody-KCNB2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNB2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNB2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for KCNB2. It may not necessarily be applicable to this product.

NCBI GI #
27436974
NCBI GeneID
9312
NCBI Accession #
NP_004761.2
UniProt Primary Accession #
Q92953
UniProt Secondary Accession #
Q7Z7D0; Q9BXD3
UniProt Related Accession #
Q92953
GenBank Nucleotide #
NM_004770.2
NCBI Official Full Name
potassium voltage-gated channel subfamily B member 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily B member 2
NCBI Official Symbol
KCNB2
NCBI Official Synonym Symbols
KV2.2
UniProt Protein Name
Potassium voltage-gated channel subfamily B member 2
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv2.2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNB2
NCBI Protein Information
potassium voltage-gated channel subfamily B member 2

NCBI Summary for KCNB2

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNB2

Kv2.2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: dendrite; integral component of membrane; perikaryon; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; protein heterodimerization activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; protein homooligomerization; regulation of smooth muscle contraction
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Research Articles on KCNB2

1. Kv2.1, but not Kv2.2 (KCNB2), forms clusters of 6-12 tetrameric channels at the plasma membrane and facilitates insulin exocytosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KCNB2 elisa kit

 Reference Product  PubMed Publications
 KCNA4 elisa kit  >1 publications with KCNB2 and KCNA4
 KCNQ2 elisa kit  >1 publications with KCNB2 and KCNQ2
 KCNH5 elisa kit  >1 publications with KCNB2 and KCNH5
 KCNAB3 elisa kit  >1 publications with KCNB2 and KCNAB3

Pathways associated with KCNB2 elisa kit

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with KCNB2 elisa kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with KCNB2 and Nervous System Diseases
 Death Antibodies  >1 publications with KCNB2 and Death
 Neurologic Manifestations Antibodies  >1 publications with KCNB2 and Neurologic Manifestations

Organs/Tissues associated with KCNB2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with KCNB2 and Brain
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