Yorkie Homolog (YAP1) ELISA Kit for Mouse

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

YAP1: an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules.

Protein type: Oncoprotein; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 9|9 A1

Cellular Component: cytoplasm; cytosol; membrane; nucleus; TEAD-1-YAP complex; TEAD-2-YAP complex; transcription factor complex

Molecular Function: activating transcription factor binding; chromatin binding; proline-rich region binding; protein binding; protein C-terminus binding; protein heterodimerization activity; transcription coactivator activity; transcription corepressor activity; transcription regulatory region DNA binding

Biological Process: cell morphogenesis; cell proliferation; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to retinoic acid; embryonic heart tube morphogenesis; keratinocyte differentiation; lateral mesoderm development; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of stem cell differentiation; notochord development; paraxial mesoderm development; positive regulation of canonical Wnt signaling pathway; positive regulation of cell proliferation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of organ growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; progesterone receptor signaling pathway; protein complex assembly; regulation of cell proliferation; regulation of keratinocyte proliferation; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of stem cell proliferation; regulation of transcription, DNA-templated; response to progesterone; somatic stem cell maintenance; transcription, DNA-dependent; vasculogenesis