Probable Jmjc Domain-Containing Histone Demethylation Protein 2c (JMJD1C) ELISA Kit for Human

Name: Human JMJD1C ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS282331
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS282331

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate JMJD1C in samples. An antibody specific for JMJD1C has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyJMJD1C present is bound by… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C), ELISA Kit

Full Product Name

Human Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C) ELISA Kit

Product Gene Name

JMJD1C elisa kit

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Other biological fluids

Specificity

This assay has high sensitivity and excellent specificity for detection of Human JMJD1C. No significant cross-reactivity or interference between Human JMJD1C and analogues was observed.

Preparation and Storage

Store at 2-8 degree C.

Molecular Weight

263,157 Da

OMIM

EF068222 mRNA

3D Structure

ModBase 3D Structure for Q15652

Sample Volume

1-200 uL

Precision

Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV

Detection Wavelength

450 nm

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of JMJD1C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JMJD1C purchase

MBS282331 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing JMJD1C. The ELISA analytical biochemical technique of the MBS282331 kit is based on JMJD1C antibody-JMJD1C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect JMJD1C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, JMJD1C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for JMJD1C. It may not necessarily be applicable to this product.

NCBI GI #

545479072

NCBI GeneID

221037

NCBI Accession #

NP_001269877.1

UniProt Primary Accession #

Q15652

UniProt Secondary Accession #

Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7; A0T124

UniProt Related Accession #

Q15652

GenBank Nucleotide #

NM_001282948.1

NCBI Official Full Name

probable JmjC domain-containing histone demethylation protein 2C isoform c

NCBI Official Synonym Full Names

jumonji domain containing 1C

NCBI Official Symbol

JMJD1C

NCBI Official Synonym Symbols

KDM3C; TRIP8; TRIP-8

UniProt Protein Name

Probable JmjC domain-containing histone demethylation protein 2C

UniProt Synonym Protein Names

Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8

Protein Family

Probable JmjC domain-containing histone demethylation protein

UniProt Gene Name

JMJD1C

UniProt Synonym Gene Names

JHDM2C; KIAA1380; TRIP8; TR-interacting protein 8; TRIP-8

NCBI Protein Information

probable JmjC domain-containing histone demethylation protein 2C

NCBI Summary for JMJD1C

The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

UniProt Comments for JMJD1C

TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: chromatin; intracellular; nucleoplasm; nucleus

Molecular Function: chromatin DNA binding; dioxygenase activity; histone demethylase activity (H3-K9 specific); metal ion binding; protein binding; thyroid hormone receptor binding

Biological Process: blood coagulation; histone H3-K9 demethylation; regulation of transcription, DNA-templated; transcription, DNA-dependent

Research Articles on JMJD1C

1. Study provides evidence that SNPs of JMJD1C and KCNQ1 are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with JMJD1C elisa kit

Reference Product	PubMed Publications
DPF3 elisa kit	>1 publications with JMJD1C and DPF3

Pathways associated with JMJD1C elisa kit

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Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
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Diseases associated with JMJD1C elisa kit

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>1 publications with JMJD1C and Brain Diseases
Heart Diseases Antibodies	>1 publications with JMJD1C and Heart Diseases
Liver Diseases Antibodies	>1 publications with JMJD1C and Liver Diseases
Mental Disorders Antibodies	>1 publications with JMJD1C and Mental Disorders
Cognition Disorders Antibodies	>1 publications with JMJD1C and Cognition Disorders
Inflammation Antibodies	>1 publications with JMJD1C and Inflammation
Nervous System Diseases Antibodies	>1 publications with JMJD1C and Nervous System Diseases
Autistic Disorder Antibodies	>1 publications with JMJD1C and Autistic Disorder

Organs/Tissues associated with JMJD1C elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9 publications with JMJD1C and Blood
Heart Antibodies	>6 publications with JMJD1C and Heart
Brain Antibodies	>4 publications with JMJD1C and Brain
Muscle Antibodies	>3 publications with JMJD1C and Muscle
Thyroid Antibodies	>2 publications with JMJD1C and Thyroid
Testis Antibodies	>2 publications with JMJD1C and Testis
Liver Antibodies	>2 publications with JMJD1C and Liver
Prostate Antibodies	>2 publications with JMJD1C and Prostate
Intestine Antibodies	>1 publications with JMJD1C and Intestine
Lung Antibodies	>1 publications with JMJD1C and Lung